Pancreatic cancer

Question 1

genetic syndromes associated with pancreatic cancer

Answer 1

BRCA1 and 2
PALB2
CDKN
ATM
STK11
Li fraumeni

Question 2

most common somatic mutation in pancreatic cancer

Answer 2

KRAS

Question 3

Resectable pancreatic cancer

Answer 3

• no arterial involvement
• less than 180 degree contact
  **Without vein contour irregularity

Question 4

To do prior to distal pancreatectomy and splenectomy

Answer 4

Vaccinate for encapsulated bacteria

Question 5

borderline resectable pancreatic cancer

Answer 5

• abutting artery but less than 180 degrees
• venous involvement greater than 180 degrees

Question 6

oxali SE’s

Answer 6

laryngopharyngeal dysesthesia
paresthesia
urticaria
anaphylaxis

Question 7

Irinotecan SE’s

Answer 7

diarrhea
hyperbili
acute cholinergic syndrome
increased salivation

Question 8

Clinical benefit of maintenance PARP for BRCA mutant

Answer 8

PFS, no OS benefit

Question 9

Unresectable pancreatic cancer

Answer 9

Head/uncinate process:
- >180 contact with SMA or celiac axis
Pancreatic body/tail:
- >180 contact with the SMA or CA
*any aortic involvement
*any celiac axis contact

Question 10

Borderline resectable pancreatic cancer

Answer 10

*Solid tumor contact with IVC
*solid tumor contact with SMV or PV of >180 or contact of <180 with contour irregularity of vein or thrombosis of vein
Head/uncinate process:
- SMA contact <180
Body/tail:
- solid tumor contact with the CA of <180