MPN Flashcards
1
Q
What are examples of clonal driver mutations seen in CHIP?
A
- TET2
- DNMT3A
2
Q
Low risk vs. high risk PV
A
- in low risk, just ASA + phlebotomy
- high risk patients need cytoreduction
3
Q
Preferred cytoreduction for age less than 40
A
interferon vs. ropeginterferon
4
Q
preferred cytoreductive drug for PV patients intolerant
A
jakafi
5
Q
Contraindications to interferon
A
depression or autoimmune disease
6
Q
What does risk stratification tool for thrombosis in ET include?
A
- age over 60
- CV risk factors
- previous VTE
- JAK2V617 (more thrombogenic)
7
Q
When is cytoreduction indicated in ET?
A
- only in high risk (like in PV)
8
Q
Low risk MF management
A
- observation if asymptomatic
- ESA if anemic
- lenalidomide if del(5q)
- hydrea if symptomatic splenomegaly
9
Q
Jakafi mechanism
A
JAK1 + JAK2 inhibitor
10
Q
mutation to know for systemic mastocytosis
A
KIT D816V
11
Q
mastocytosis clinical features
A
- flushing, pruritus, urticaria
- GI tract involvement
- lymphadenopathy + splenomegaly
12
Q
drugs approved for systemic mastocytosis
A
- midostaurin
- avapritinib
13
Q
CNL treatment
A
jakafi
