Gyn Onc

Question 1

Management of early stage cervical cancer in general

Answer 1

• Early stage cervical cancer.
  Upfront surgery (cervical conization vs. modified radical vs. radial hysterectomy depending on stage)
• Adjuvant chemoradiation if path indicates intermediate or high-risk of recurrence

Question 2

Surgical management of early stage cervical cancer

Answer 2

IF IA1, conization w/ no further management if margins negative
IF IA2,
modified radical hysterectomy (removal of uterus, cervix, upper ¼ of vagina, and paramteria)
simple hysterectomy w/ lymphadenectomy
IF IB1, radical hysterectomy w/ lymphadenectomy
IF IB2, radical hysterectomy

Question 3

First line for MMR deficient advanced endometrial

Answer 3

carbo/taxol/durvaluma w/ maintenance durvalumab until progression (DUO-E - PFS HR 0.42 in dMMR, OS immature)