Random virus facts

Question 1

Rubella sequelae in mother and child?

Answer 1

Mother: polyarthralgia, post-auricular lymphadenopathy
Child: Cataracts, deafness, PDA

Question 2

Measles: what vitamin supplement?

Answer 2

Vitamin A supplementation reduces recovery time.

Question 3

Where do DNA viruses replicate? Where do RNA viruses replicate?

Answer 3

DNA viruses: all in the nucleus, except for big fat poxvirus which brings its own enzymes, and except for Hepadnavirus (hep B) which replicates partially in the cytoplasm and partially in the nucleus.
RNA viruses: all in the cytoplasm except orthomyxovirus (influenza) and retroviridae (HIV)

Question 4

What does polycistronic mean? Which viruses are polycistronic?

Answer 4

Polycistronic means more than one protein from a single transcript (eukaryotes are monocistronic, bacteria are polycistronic).

Linear +ssRNA viruses (eg picorna)

Question 5

+ssRNA viruses?

Answer 5

I went to a RETRO TOGA party, where we drank FLAVored CORONA, and ate HIPPY PICkles

Retrovirus, togavirus, flavivirus, coronavirus, hepevirus, picornavirus

Question 6

Which are the circular DNA viruses?

Answer 6

All except:

Polyoma, papilloma (circular, supercoiled)
Hepadna (incomplete circular)

Question 7

Which are the segmented RNA viruses?

Answer 7

BOAR

Bunyaviruses, Orthomyxoviruses, Arenaviruses, Reovirus

Question 8

Which are the flaviviruses?

Answer 8

HCV

Arbo: Yellow Fever, Dengue, St. Louis, West Nile

Question 9

Which are the bunyaviruses?

Answer 9

ARBO: California encephalitis, Sandfly/rift valley, Crimean-Congo

ROBO: Hantavirus

Question 10

Which are the arenaviruses?

Answer 10

ROBO: Lassa, junin, sabia

LCMV - lymphocytic choriomeningitis virus

Question 11

Which are the togaviruses?

Answer 11

Rubella

ARBO: EEE, WEE

Question 12

What are the HIV structural proteins?

Answer 12

gag - codes for p24 capsid protein
pol - codes for RT, protease, integrase
env - codes for gp160 (cleaved to gp120, gp41)
tat - regulatory function