autoantibodies

Question 1

SLE antibodies?

Answer 1

ANA - sensitive but not specific for SLE

anti-dsDNA - specific for SLE

anti-Smith aka anti-snRNP - specific for SLE, but not sensitive.

anti-histone - drug induced lupus

Question 2

anti-citrullinated peptides?

Answer 2

specific for RA. anti-RF is not as specific.

Question 3

CREST/systemic sclerosis abx?

Answer 3

anti-centromere and anti-Scl-70 (DNA Topo I), respectively

Question 4

antimitochondrial abx?

Answer 4

primary biliary cirrhosis

Question 5

IgA anti-endomysial?

Answer 5

Celiac dz, along with IgA anti-transglutaminase

Question 6

anti-desmoglein?

Answer 6

pemphigus vulgaris

Question 7

anti-microsomal, antithyroglobulin

Answer 7

Hashimotos

Question 8

Sjorgen’s abx?

Answer 8

anti-SSA (anti-Ro), anti-SSB (anti-La)

Question 9

anti-Jo-1, anti-SRP, anti-Mi-2

Answer 9

Dermatomyositis, polymyositis

Question 10

anti-U1 RNP

Answer 10

mixed connective tissue dz

Question 11

anti-smooth muscle

Answer 11

autoimmune hepatitis

Question 12

anti-glutamate decarboxylase

Answer 12

type I DM

Question 13

c-ANCA (PR3)

Answer 13

Wegener’s

Question 14

p-ANCA (MPO)

Answer 14

MPA, Churg-Strauss