Random drugs

Question 1

Denosumab

Answer 1

Monoclonal (fully human!) soluble decoy receptor for RANKL. Used in osteoporosis.

Question 2

Pallifermin

Answer 2

Recombinant keratinocyte growth factor. Protects oral mucosa and skin during chemo and radiation treatment.

Question 3

Vesamicol

Answer 3

Inhibits presynaptic vesicular Ach transporter. Like a cholinergic version of Reserpine.

Question 4

Reserpine

Answer 4

Inhibits presynaptic vesicular monoamine transporter (VMAT). Like a noradrenergic version of vesamicol.

Question 5

Hemicholinium

Answer 5

Inhibits presynaptic choline transporter into neuron (this is the rate-limiting step in Ach synthesis).

Question 6

Metyrosine

Answer 6

Tyrosine hydroxylase inhibitor. Can be used for pheo.

Question 7

Guanethidine and Bretylium

Answer 7

Presynaptic cholinergic blocker. Replaces norepinephrine in transmitter vesicles.

Question 8

Phenoxybenzamine vs Phentolamine

Answer 8

Phenoxybenzamine: irreversible alkylator of alpha receptors. t1/2 = 24 hrs. Oral dosing.

Phentolamine: reversible inhibitor of alpha receptors. t1/2 = 20 mins. IV or IM.