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1
Q

Unconjugated hyperbilirubinemia. AD. Decreased UGT1A1 activity. Mild, but occasionally causes kernicterus

A

Crigler Najjar Syndrome Type 2

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2
Q

Unconjugated hyperbilirubinemia. AR. Decreased UGT1A1. Innocuous

A

Gilbert

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3
Q

AR. Conjugated hyperbilirubinemia. Decreased biliary excretion. Innocuous

A

Dubin-Johnson

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4
Q

Mutation in Canalicular MDR protein 2 (MRP2)

A

Dubin-Johnson

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5
Q

Pigmented cytoplasmic globules in liver

A

Dubin-Johnson

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6
Q

AR. Conjugated hyperbilirubinemia. Decreased hepatocyte uptake and storage. Decreased biliary excretion. Innocuous.

A

Rotor syndrome

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7
Q

Hem > biliverdin by

A

Heme oxygenase

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8
Q

Biliverdin > unconjugated bilirubin by

A

Biliverdin reducatase

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9
Q

Unconjugated bilirubin > conjugated bilirubin by

A

UDPGT (glucuronyl-bilirubin transferase)

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10
Q

Conjugated bilirubin is excreted in

A

Bile

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11
Q

Stercobilin is excreted in

A

Stool

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12
Q

Urobilin is excreted in

A

Urine

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13
Q

Unconjugated hyperbilirubinemia. AR. No UGT1A1 activity. Fatal in neonatal period.

A

Craiger Najjar syndrome type 1

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14
Q

Middle aged and older. Common in USA. ANA and ASMA

A

Type 1 autoimmune hepatitis

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15
Q

Children and teenagers. Southern Europe. Anti-LKM1

A

Type 2 autoimmune hepatitis

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16
Q

Attacks CYP2D6 on plasma membrane of cell

17
Q

Cholestasis, vascular lesions, neoplasms

18
Q

Fatty liver disease, fibrosis, cirrhosis, neoplasms

19
Q

Fatty liver disease, fibrosis, cirrhosis

A

Methotrexate

20
Q

Hepatocellular necrosis

A

Acetaminophen

21
Q

Max daily dose of acetaminophen is

22
Q

Chlorpromazine and halothane are directly toxic to the

23
Q

Increased lipid synthesis, increased peripheral fat catabolism, and abnormal lipoproteins

24
Q

Reversible with abstinence

25
Q

Macro and micro vesicular steatosis. Mallory-Denk bodies

A

Alcoholic liver disease

26
Q

80 grams or more alcohol daily

A

Severe liver injury

27
Q

Iron overload, Hep B, and Hep C are _____ with alcohol

A

Synergistic - cause more severe effects

28
Q

Necrosis, inflammation, Mallory bodies, fatty change

29
Q

AST > ALT

A

Alcoholic hepatitis

30
Q

Perisinusoidal and pericellular fibrosis (chicken wire)

A

Alcoholic cirrhosis

31
Q

Degree of fibrosis

32
Q

Degree inflammation, necrosis, and steatosis

33
Q

Most common cause of increased liver enzymes

A

Non-alcoholic steatohepatitis

34
Q

No inflammation, cell death, or fibrosis in

A

Non-alcoholic steatohepatitis

35
Q

Just have Microvesicular steatosis

A

Non-alcoholic steatohepatitis

Exam 14 (22 decks)

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