Limjoco 2 Flashcards
Hilar location of this tumor will cause symptoms of biliary obstruction (Klatskin tumor)
Cholangiocarcinoma
Elevated serum CA19-9
Cholangiocarcinoma
Firm, gray-white tumor
Cholangiocarcinoma
Disorderly tubular glands in sclerotic stroma
Cholangiocarcinoma
Difficult to diagnose and treat. Can cause biliary obstructive symptoms. Do surgical resection if possible (whipple’s procedure). Transplant if liver is resected
Cholangiocarcinoma
Most common primary sarcoma of the liver
Angiosarcoma
Primary malignant pediatric liver cell tumor. Most common primary liver tumor of childhood
Hepatoblastoma
Hepatoblastoma is ___ if not treated
Fatal
Associated with beckwith-wiedemann syndrome and FAP
Hepatoblastoma
Epithelial type of ______ has best prognosis
Hepatoblastoma
Cords of small hepatocytes. Light and dark herringbone pattern
Fetal epithelial type hepatoblastoma
Can be associated with extrahepatic disease. Elevated AFP.
Hepatoblastoma
With hepatoblastoma, if AFP is low/normal, it is
More aggressive
May be caused by drugs to maintain a low birth weight infant
Hepatoblastoma
Treat ________ with chemo and surgical resection
Hepatoblastoma
Colon, breast, lung, and pancreas
Liver mets
Neuroblastoma, Wilms tumor, and rhabdomyosarcoma
Children liver mets
___________ most common cause of jaundice in pregnancy
Viral hepatitis
Toxemia of pregnancy
Eclampsia
Elevated aminotransferases, ALP, and bilirubin
Preeclampsia and eclampsia
Periportal sinusoidal deposits of fibrin. Coagulative hepatocyte necrosis
Preeclampsia and eclampsia
Hemolysis, elevated liver enzymes, low plts
HELLP syndrome
Multisystem d/o that presents in last trimester with RUQ pain, N/V, and edema
HELLP syndrome
Periportal sinusoids with fibrin and hemorrhage in space of Disse
HELLP syndrome
Seen in third trimester. Defects in mitochondrial FA beta-oxidation. Can have mild changes (elevated serum transaminases) or liver failure, coma, and death.
Acute fatty liver of pregnancy
May be due to coexistent preeclampsia
Acute fatty liver of pregnancy
Microvesicular steatosis, scant inflammation and necrosis
Acute fatty liver of pregnancy
Seen in third trimester of multiparious women. Hx of Cholestasis with OC use. Pruritus
Intrahepatic cholestasis of pregnancy
Pruritus, jaundice, darkening urine, and lightening stools. Conjugated hyperbilirubinemia, ALP elevated. Bile salts markedly increased
Intrahepatic cholestasis of pregnancy
Mutations in phospholipid translocation, ATP cassette transporter B4
Intrahepatic cholestasis of pregnancy
Biliary defects in secretion of bile salts or sulfated progesterone metabolites
Intrahepatic cholestasis of pregnancy
Benign. But increased fetal distress, still births, and prematurity
Intrahepatic cholestasis of pregnancy
Second most common malignant primary hepatic tumor. Arises from ducts within and outside liver. Incidence increased 3X in 70’s-90’s
Cholangiocarcinoma
