Limjoco

Question 1

Due to heterogenous microcirculation from obliteration of small portal veins and arterialization

Answer 1

Nodular regenerative hyperplasia

Question 2

Associated with many different diseases (rheumatoid arthritis, lupus, systemic sclerosis, PAN, polycythemia Vera, chronic Granulomatous diseases, cystinosis, mastocytosis, amyloidosis)

Answer 2

Nodular regenerative hyperplasia

Question 3

Nodular regenerative hyperplasia will have _______ ALP and GGT

Answer 3

Elevated

Question 4

Nodular regenerative hyperplasia ____ fibrosis, unlike cirrhosis

Answer 4

Lacks

Question 5

Benign tumor of hepatocytes. Seen in young women of reproductive age who have taken oral contraceptives and men on androgen therapy

Answer 5

Hepatocellular adenoma

Question 6

Usually solitary. Pale, yellow-tan. Only has sheets and cords of normal liver cells

Answer 6

Hepatocellular adenoma

Question 7

Well circumscribed, unencapsulated pale tumor

Answer 7

Hepatocellular adenoma

Question 8

Only see proliferation of hepatocytes and thin vessels. No biliary channels or portal tracts

Answer 8

Hepatocellular adenoma

Question 9

Mistaken for HCC

Answer 9

Hepatocelluar adenoma

Question 10

Subcapsular tumor can rupture, especially during pregnancy. Rarely transforms into carcinomas (except during glycogen storage disease)

Answer 10

Hepatocellular adenoma

Question 11

Most common benign liver tumor.

Answer 11

Cavernous hemangioma

Question 12

Discrete, Subcapsular red-blue soft nodule

Answer 12

Cavernous hemangioma

Question 13

Asymptomatic. Incidentally found in middle aged female. Can rupture

Answer 13

Cavernous hemangioma

Question 14

Diagnose cavernous hemangioma by

Answer 14

Imaging

Question 15

May present as Kasabach-Merritt syndrome (microangiopathic anemia w/ consumption coagulopathy)

Answer 15

Cavernous hemangioma

Question 16

Rarely bleeds. Can cause erythrocytosis from erythropoietin secretion

Answer 16

Cavernous hemangioma

Question 17

Malignant liver tumor arising from hepatocytes. Most common primary malignant liver tumor in adults. Usually Arise in setting of cirrhosis

Answer 17

HCC

Question 18

Associated with Hep B in SE Asia, Africa, and China

Answer 18

HCC

Question 19

Main cause of increase in incidence in the 1990s in the USA was Hep B and Hep C

Answer 19

HCC

Question 20

Associated with alcoholic and non-alcoholic cirrhosis, NASH, hemochromatosis, primary biliary cirrhosis, AIH, aflatoxin

Answer 20

HCC

Question 21

Obesity related fatty liver disease and NASH is increasing, which will cause an increase of this in coming decades

Answer 21

HCC

Question 22

HCC has ____ AFP

Answer 22

Elevated

Question 23

_________ is increased in HCC, chronic Hep C, and cirrhosis

Answer 23

AFP

Question 24

Paler than surrounding parenchyma. May be green. Propensity for vascular invasion > mets.

Answer 24

HCC

Question 25

Develops about 10 yrs after cirrhosis

Answer 25

HCC

Question 26

Seen in young adults (20-40 yrs). Seen in the absence of underlying liver disease or cirrhosis

Answer 26

Fibrolamellar variant of HCC

Question 27

Same clinical manifestations as usual HCC, but has better prognosis

Answer 27

Fibrolamellar variant of HCC

Question 28

Transformation of entire liver into multiple 1-2 mm nodules w/o fibrous septa between nodules

Answer 28

Nodular regenerative hyperplasia