Drug Tx

Question 1

26 wks - 1 month after birth

Answer 1

Perinatal

Question 2

5-52 wks after birth

Answer 2

Infant

Question 3

> 1 yr old

Answer 3

Child

Question 4

Gastric pH _________ during first 24 hrs after birth.

Answer 4

Decreases

Question 5

Gastric emptying delayed during first __________ days after birth

Answer 5

2

Question 6

GFR __________ by 50% during first week after birth

Answer 6

Increases

Question 7

GFR attains adult levels between _________ months

Answer 7

6-12

Question 8

Metabolism in neonate is dependent on drug treatment/environmental exposure of

Answer 8

Mother

Question 9

0-4 wks

Answer 9

Neonate

Question 10

Phenytoin and Indomethacin will displace

Answer 10

Bilirubin

Question 11

30% decrease in GFR. 60% reduction in urine flow rate. Variable effects on electrolytes (may cause hyponatremia)

Answer 11

Indomethacin

Question 12

Most common diuretic given to neonates

Answer 12

Furosemide

Question 13

Immature kidney has decreased

Answer 13

Perfusion (receives 5% of CO at birth)

Question 14

Neonates display a delayed response to

Answer 14

Furosemide

Question 15

Dosages calculated from _________ are more accurate

Answer 15

Surface area

Question 16

Dosages by body weight can

Answer 16

Under estimate dose

Question 17

Noxious or unwanted response that occurs at a dose that’s usually therapeutic

Answer 17

Adverse drug rx

Question 18

Unexpected response of the immune system

Answer 18

Hypersensitivity reaction

Question 19

CO declines 1%/yr after the age of

Answer 19

30

Question 20

GFR declines 0.5%/yr after age of

Answer 20

20

Question 21

Tubular secretion decreases

Answer 21

0.5%-1%/yr

Question 22

Less absorption of ferrous sulfate and ketoconazole in elderly b/c of

Answer 22

Increased stomach pH

Question 23

Use of ________ lowers absorption of cimetidine, digitalis, tetracycline, and phenytoin

Answer 23

Antacids

Question 24

Diazepam, flurazepam, and amiodarone

Answer 24

Lipid soluble drugs

Question 25

Ethanol, procainamide, and atendol

Answer 25

Water soluble drugs

Question 26

______ binds to muscle Na-K ATPase

Answer 26

Digoxin

Question 27

_________ can be decreased by renal disease, uremia, acidic states, and low protein diet

Answer 27

Protein binding

Question 28

Acetyl Salicylic acid can displace binding of

Answer 28

Warfarin

Question 29

Barbiturates, diazepam, flurazepam, nortriptyline, propanolol, theophylline, chlordiazepoxide have age related

Answer 29

Decrease in hepatic clearance

Question 30

Ethanol, lorazepam, nitrazepam, oxazepam, warfarin, and Salicylates all are

Answer 30

Worked on by phase 2 rxs and do no have age related decreased in hepatic clearance

Question 31

Increased receptor response in elderly to

Answer 31

Opiates and benzodiazepines

Question 32

Greater sedation in elderly with

Answer 32

Morphine or diazepam

Question 33

Greater incidence of complications with ________ in elderly

Answer 33

Diuretics

Question 34

_____ can cause potassium and magnesium depletion

Answer 34

Thiazides

Question 35

_____ can cause potassium depletion

Answer 35

Furosemide

Question 36

______ have increased responsiveness to phenothiazines

Answer 36

Elderly

Question 37

Chlorpromazine can worsen _____ in elderly

Answer 37

Orthostatic hypotension

Question 38

_____ requires renal excretion and dose must be adjusted in elderly

Answer 38

Lithium

Question 39

Black box warning for using typical and atypical ____________ in elderly

Answer 39

Dopamine antagonists