Poison Flashcards
OD of barbiturates, opiates, and alcohol worsens
Respiratory depression
______ urine for acidic drugs to enhance elimination
Alkalinize
Syrup of ipecac acts via
Emesis
Used for OTC agents, drugs/pills in table form, pesticides, iron containing vitamins
Emesis (syrup of ipecac)
Avoid ______ in corrosive agents, petroleum distillates, loss of gag reflex, and convulsions (TCAs, strychnine, and gamma hydroxy butyrate)
Emesis
_______ risk of pneumonitis > systemic toxicity
Petroleum distillates
_______ contraindicated in the home for ammonia, drain cleaners, electric dishwater cleaners, kerosene, motor oil, and furniture polish
Emesis
Ammonia, drain cleaners, and electric dishwater cleaners act as
Caustic substances
Kerosene, motor oil, and furniture polish can cause
Pulmonary hydrocarbon pneumonitis
Contraindicated in corrosives, caustics, or sharp objects
Lavage with activated charcoal
Ineffective for acids, alkalis, some pesticides, metals, and petroleum distillates
Activated charcoal
Acetaminophen, amphetamines, aspirin, benzodiazepines, barbiturates, carbamazepines, digoxin, phenothiazines, nicotine, theophylline, strychnine, and malathion can be treated with
Activated charcoal
Opiate antagonist used to reverse respiratory depression
Naloxone
Benzodiazepine antagonist
Flumazenil
Used to enhance excretion of acidic drugs
Sodium bicarb
Most likely in children
Petroleum distillates
Major toxicity is aspiration and chemical pneumonitis
Petroleum distillates
_______ viscosity increases potential to flow into airways
Low
Best indicator of aspiration potential is
Viscosity
______ target the lung, cardiovascular system, and CNS
Aerosol propellants
Most deaths are due to cardiac arrest
Aerosol propellants
Contains benzene > cause leukemia
Gasoline
Causes ophthalmic and auditory nerve damage
Toluene
_______ during pregnancy will cause increased fetal death risk and low birth weight
Huffing
No antidote available, treat symptoms
Aerosol propellants
Minimal toxic dose >20 mg/kg of
Elemental iron
__________ to remove iron tablets
Emesis
Causes centrilobular necrosis in the liver
Acetaminophen
Causes proximal tubular necrosis in the kidney
Acetaminophen
N-acetyl-benzoquinoneimine (NAPQI)
Toxic metabolite of acetaminophen
Hepatotoxic metabolite
NAPQI
Detoxified by glutathione conjugation
NAPQI
Delayed appearance of hepatic toxicity
Acetaminophen
Antidote > N-acetylcysteine orally
Acetaminophen
Iron containing vitamins, pesticides, OTC cold remedies, cleaning supplies
Common poisons children