Drug Interactions 2

Question 1

Poor metabolizers have _____ response to medications

Answer 1

Greater

Question 2

Probenecid inhibits tubular secretion of ______, amplifying its effects

Answer 2

Pencillin

Question 3

Methotrexate and sulfamethoxazole compete for _______. Results in methotrexate toxicity

Answer 3

Tubular secretion

Question 4

Omeprazole inhibits K, H - ATPase blocking the secretion of this drug in the kidney, causing higher serum levels and toxicity

Answer 4

Methotrexate

Question 5

Trimethoprim increases distal renal tubular absorption of ____ causing _____

Answer 5

Potassium - hyperkalemia

Question 6

Quinidine inhibits tubular secretion of _________ via PGP. Results in digoxin toxicity

Answer 6

Digoxin

Question 7

Unionized drugs are often reabsorbed into the

Answer 7

Blood stream

Question 8

Low pH cause an acidic drug to be in its _____ form

Answer 8

Unionized

Question 9

Carbonic anhydrase inhibitors ___ urine pH. Causes an increased reabsorption of quinidine

Answer 9

Increase

Question 10

Quinidine associated with

Answer 10

Cardiotoxicity

Question 11

______ taken with acetazolamide increases its toxicity

Answer 11

Aspirin

Question 12

Macrolides - azithromycin

Answer 12

Less potential for interactions

Question 13

Macrolides - erythromycin, clarithromycin both affect

Answer 13

P450 > higher potential for interactions

Question 14

Cimetidine inhibits

Answer 14

P450 - higher risk of interaction

Question 15

H2 blocker ranitidine

Answer 15

Lower risk of interaction

Question 16

Pravastatin and fluvastatin

Answer 16

Less potential for interaction

Question 17

Lovastatin

Answer 17

Prodrug > more potential for interaction

Question 18

Atorvastatin has

Answer 18

Active metabolites > more potential for interaction

Question 19

Asians, African Americans, and white Americans are poor metabolizers via

Answer 19

CYP2C19