RA Flashcards
3 classes of drug for RA?
-NSAIDS
Rapid relief of sxs; don’t prevent joint damage
-higher doses
-Glucocorticoids
Rapid relief of sxs; slow progression
Long term use = toxicity –>therefore short courses
-DMARDs
Reduce joint destruction
More toxic than NSAIDS
Biologic and non-biologic
these 2 drug classes for RA provide rapid relief of sxs
NSAID and Glucocorticoid
This class of drugs for RA will reduce joint destruction
DMARDS
This class of RA drugs is high risk for toxicity long term so we only use it for short term
glucocorticoid
What does DMARD stand for- 10 points if you get this!
Disease modifying antirheumatic drugs
2 classes of DMARD
Biologic and Non biologic
What is prototype for non-biologic DMARD
Methotrexate (Rheumatrex)
What is prototype for Biologic DMARD
etanercept (TNF antagonist)
RA drug that you need to take folic acid supplement with? Why?
Methotrexate (Rheumatrex)
–> 5 mg/week will decrease GI sxs
This DMARD is category X pregnancy
Methotrexate (Rheumatrex)
Side effects of Methotrexate (Rheumatrex)
(non biologic DMARD)
hepatic fibrosis, bone marrow suppression, GI ulceration, pneumonitis
–>Reduced life expectancy from CV disease, infection and certain cancers
How do biologic DMARDS work?
target the specific parts of the inflammatory process
examples:
- Tumor Necrosis Factor
- Promotes destruction of B cells
- Inhibits activation of T cells
which RA drug is serious risk of infection?
Biologic DMARD –> etanercept
Which drug do you need to for TB/Hep B/ fungal infection before starting?
Biologic DMARDs ( Tumor Necrosis Factor Antagonists Prototype: etanercept)
Which DMARD is super pricey- 14-35k annually?
Tumor Necrosis Factor Antagonists Prototype: etanercept
