exam 3 Flashcards
drugs we need to know about overdosing/toxicity
imipramine- suicide risk, messes up your<3
lithium - no antidote- .4-.8
phenytoin- 10-20 mcg
triazolam
schedule 5?
gabapentin, pregabalin
no grapefruit and rash report?
carbamezapine (epilpep)
epileptic drug that is hepatotoxic and blood dyscrasia?
valproic acid
purple glove and gums?
phenytoin
Temporary paresthesia and itching (groin)
fosphenytoin
drug increases its own metabolism?
carbamezepine
Serotonin Syndrome (SES) vs Serotonin Withdrawal Syndrome
—–Serotonin Withdrawal Syndrome
Dizziness, headache, nausea, sensory disturbances, tremor, anxiety, dysphoria
- Begins within days to weeks , Persists 1-3 weeks
—–Serotonin Syndrome (SES)
mental status changes, hypertension, tremors, fever and sweats, hyperpyrexia, or ataxia
-2-72 hours after treatment starts
these 2 block reuptake if serotonin and NE
imipramine (Tofranil)
venlafaxine (Effexor)
imiprinine does not play nice w/ which other class of antidepressant?
MAOI
drugs to give @ bedtime
-imipramine
late in day = donepezil
take in morning
- alendronate
- fluoxetine
- selegiline
- pramipexole
MAOI + other antidepressant or sympathomimetic=
hypertensive crisis
MAOI + antihypertensive=
hypotension
MAOI + antidiabetic drugs=
hypoglycemia
MAOI + meperidine (Demerol)=
hyperpyrexia
14 day window b/w taking antihypertensive, antidiabetic, meperidine, other antidepressants with _______
MAOI
MAOI + Tyramine foods =
hypertensive crisis
dosing for colchicine
1.2 mg loading then .6 mg I hr later. Max 1.8/24 hrs.
no grapefruit and rhabdo?
colchicine
this drug has only one regular side effect but cannot play with warfarin
allopurinol
penia vs porosis scores
Osteopenia- low bone mass T-score -1 to -2.5
Osteoporosis- T score -2.5 or more
calcium + ______ _______ containing foods = sad
oxalic acid
dosing for Ca and Vit D
Ca = 1200 / 2
Vit D = 800-1000
intranasal Osteoporosis drug?
calcitonin salmon
OP drug w/ esophagitis risk
alendronate
2 drugs w/ osteonecrosis of jaw risk
alendronate
denosumab
OP drug w/ risk for DVT an PE
SERM - think blood SERuM
RANKL goes w/ who
denosumab
RANK receptor stimulates formation of osteoclasts
-this drug prevents receptor activation and inhibits osteoclast formation- aka RANKL inhibitor
SQ OP drugs
calictonin-salmon
denosumab
teripartide
Deno came to Teri’s party in Cali
SQ- etanercept or methotrexate?
etanercept
test for TB prior, watch for hep b activation=
etanercept, methotrexate
use folic acid supplement to help your tummy w/ which drug
methotrexate
p.s. category x
all benzo’s potentiate
GABA
flumazenil (Romazicon) is antidote for ________. It is given how?
triazolam
over 15 seconds. Repeat Q min. Effects last 1 hour.
3 drugs = no grapefruit =
colchicine
carbamezpine
buspirone
Don’t bring a Grapefruit in my Car or the Bus or the Colcheesey factory
prolonged qt interval long term use?
hydroxyzine
prototype for benzo anxiety?
diazepam
triazolam effects what 3 systems
cns, cv, resp
avoid high protein meal with?
levadopa
anticholinergic effects with
amantadine
benztropine
imipramine
bronchoconstriction w/ what alz drug?
donepezil (increase ACH)
ACH and alz ? ACH and Parkinsons?
ALZ = not enough ACH Parkinson's = too much ACH
nystagmus w/ what 2 antiep
- phenytoin- toxicity
- gabapentin- regular side effect
suppress your bone marrow
carbamezepine
methotrexate
admin rate for phenytoin? only compatible w? what kind of fluids?
<50mg/ min = SLOW
NS
