Prototypes + class Flashcards

1
Q

class of chemo drugs that target S phase of cell cycle

A

◦ Antimetabolites

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2
Q

Class of chemo drugs that target G2 phase of cell cycle?

A

taxanes/taxoids

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3
Q

Class of chemo drugs that target M phase of cell cycle?

A

◦ Vinca alkaloids

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4
Q

Chemo drugs that have killing action REGARDLESS of cell cycle phase?

A

◦ Alkylating agents

◦ Antitumor antibodies

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5
Q

4 types of cytotoxic agents

A

a) Alkylating Agents
b) Antimetabolites
c) Antitumor antibiotics
d) Mitotic Inhibitors

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6
Q

prototype for hormone/hormone antagonist chemotherapy

A

tamoxifen (Nolvadex) –> SERM

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7
Q

2 classes of targeted therapies for cancer (nommy little bits)

A

nibs and mabs

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8
Q

2 types of biological response modifiers?

A
  1. immunostimmulants: interlukin and interferons

2. immunosuppressant

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9
Q

2 types of immunostimulants

A

interleukins

interferons

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10
Q

Classes of drugs to treat PUD (5)

A
  • Antibiotics for H.Pylori
  • Anti Secretory
  • Mucosal Protectant
  • Prostaglandin Agent
  • Antacid
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11
Q

3 types of anti secretory agents:

A
  • H2Blockers
  • Proton Pump Inhibitors
  • Muscarinic antagonist ??? (she never really talked about these but listed it. lmk if I missed a beat on this)
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12
Q

prototype of H2 blockers

A
  • Prototype: cimetidine (Tagamet) –> in the drug book, original H2 blocker
  • Also Know: famotidine (Pepcid) –> more commonly used
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13
Q

prototype for anti secretory: proton pump inhibitor

A

omeprazole (Prilosec)

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14
Q

prototype for mucosal protectant

A

Sucralfate

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15
Q

Prostaglandin Agent prototype

A

misoprostol (Cytotec)

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16
Q

different kinds of antacid compounds (elements)

A

aluminum
magnesium
calcium
sodium

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17
Q

prototype for Serotonin Receptor Antagonists

A

ondansetron (Zofran)

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18
Q

prototype for Substance P Neurokinin1Antagonists

A

aprepitant (Emend)

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19
Q

prototype for Glucocorticoids

A

dexamethasone (Decadron)

20
Q

prototype for Benzodiazepines for nausea

A

lorazepam (Ativan)

21
Q

prototype for phenothiazines

A

Promethazine (Phenergan)

22
Q

prototype for cannabinoids

A

dronabinol (Marinol)

23
Q

prototype for Anticholinergics/ Antihistamines for nausea

A

hydroxyzine (Vistaril)

24
Q

prototype for 5-Aminosalicylates

A

Sulfasalazine

25
Q

prototype for targeted therapy for IBD

A

Monoclonal antibodies : infliximab (Remicade)

26
Q

Antibiotics for Crohn’s

A

• Metronidazole (Flagyl) AND Ciprofloxacin (Cipro)

**nopt for UC

27
Q

prototype for bulk forming laxative

A

Psyllium (Metamucil)

28
Q

prototype for Surfactant Laxatives

A

docusate sodium (Colace)

29
Q

prototype for osmotic laxatives

A

polyethylene glycol (Miralax)

30
Q

lubiprostone (Amitiza) falls in what class of laxative?

A

misc!

31
Q

prototype for short duration RAPID acting insulin?

A

Aspart (novolog)

I want to get through the ass part very quickly

32
Q

prototype for SLOWER acting insulin?

A

RegulAR (Humulin R, Novolin R)

slowAR regulAR R R R R

33
Q

prototype for intermediate acting insulin?

A

Intermediate acting NPH (Humulin N, Novolin N)

iNtermediate Nph humulin N N N N N

34
Q

prototype for long acting insulin?

A

glargine (Lantus) (U-100)

Long Acting - LAntus, gLArgine

35
Q

prototype for Ultra-long duration Insulin

A

Insulin glargine (U-300) (Toujeo)

36
Q

prototype for combination insulin

A

NPH/regular 70/30 (Humulin 70/30)

37
Q

prototype for biguanides

A

metformin (Glucophage)

38
Q

prototype for sulfonylureas?

A

glipizide (Glucotrol XL)

39
Q

prototype for Glinides (Meglitinides)

A

repaglinide (Prandin)

40
Q

prototype for Thiazolidinediones (TZD) or “glitazones”

A

pioglitazone (Actos)

41
Q

prototype for Alpha-glucosidase Inhibitors

A

acarbose (Precose)

42
Q

prototype for SGLT-2 Inhibitors

A

canagliflozin (Invokana)

43
Q

prototype for GLP-1 Receptor Agonist/Mimetics

A

Exanatide (Byetta)

44
Q

prototype for DPP-4 Inhibitors?

A

: “gliptins” —-> Sitagliptin (Januvia)

45
Q

prototype for Amylin Mimetics

A

Pramlintide (Symlin)