Heart Failure Flashcards
Heart failure leads to inadequate ____ _____ AND/OR ____ ______
Inadequate tissue perfusion AND/OR volume overload
inability of the heart to adequately pump all the blood it has received. The lack of cardiac output thus fails to meet the metabolic needs of the body
Heart Failure
Is there a cure for heart failure?
Nope
Goal = prevent, treat, and remove UNDERLYING CAUSE
How does chronic hypertension lead to HF?
Too much afterload for too long.
Too much pressure for the L ventricle to pump against
What is cardiac remodeling?
reduced cardiac output»_space;> compensatory responses»_space;»
^increase HR
^venous/arterial pressure
What are the compensatory responses as a result of reduced cardiac output?
- Cardiac Dilation
- Activation of SNS
- Activation of RAAS
- Retention of water/increased bld volume
What does left sided HF result in?
pulmonary HTN
Pulmonary Edema –> wet lungs
What does right sided HF result in?
Veins distended
Edema in Legs
Ascites in belly
what are the 2 goals of drugs to treat HF?
- increase force of contraction (positive ionotropic effect)
- decrease HR to reduce O2 consumption
List the main classes of drugs to treat HF (7) (6 if you lump one in with another)
1.Diuretics
Thiazide Diuretics: Hydrocholorthiazide
Loop Diuretics: furosemide
K Sparing Diuretics: spironolactone
2.Drugs that Inhibit RAAS
ACE: lisinopril (Zestril)
ARB: valsartan
ARNI: sacubitril/valsartan (Ernesto)
Aldosterone receptor blocker: spironolactone
3.Beta Blockers: carvedilol (Coreg), metoprolol XL (Toprol-XL), bisoprolol (Zebeta)
4.HCN Channel Blocker :ivabradine (Crolanor
5.Cardiac Glycosides: digoxin
6.Vasodilators: isosorbide dinitrate with hydralazine
7.Acute HF drugs: IV infusions
3 diuretics to treat HF
Thiazide Diuretics: Hydrocholorthiazide
Loop Diuretics: furosemide
K Sparing Diuretics: spironolactone
Drugs that inhibit RAAS to TREAT HF
ACE: lisinopril (Zestril)
ARB: valsartan
ARNI: sacubitril/valsartan (Ernesto)
Aldosterone receptor blocker: spironolactone
1st line therapy drug class for HF? why?
diuretics!
Reduce the blood volume (preload) –> decreases workload on heart
Are diuretics a cure for HF?
reduces symptoms, does not prolong survival
3 ways diuretics treat HF
- treat pulmonary/peripheral edema
- decrease preload/afterload
- causes cardiac dilation
prototype for Loop Diruetics?
furosemide (Lasix)
how does furosemide (Lasix) fxn?
-Loop Diuretic
Inhibits reabsorption of Na & Cl at loop of Henle –> resulting in decrease BLOOD VOLUME
onset/duration for PO furosemide (Lasix)
onset 1hour - duration for 8 hours
onset/duration for IV furosemide (Lasix)
onset 5 min - duration 2-3 hours
Most efficacious diuretic for HF?
furosemide (Lasix)
which diuretics have risk of HYPOkalemia?
Thiazide Diuretics: Hydrocholorthiazide
Loop Diuretics: furosemide
What other electrolytes get messed up with Thiazide Diuretics: Hydrocholorthiazide and Loop Diuretics: furosemide
Na and Cl
Loop and Thiazide diuretics have risk of ____ and _____ toxicity
digoxin and lithium
Which HF drug has risk of transient ototoxicity? why?
Loop Diuretics: furosemide (Lasix)
-if give IV too fast
If diuretics are decreasing blood volume things are we watching for in patient
hypotension, dehydration, postural hypotension, hypovolemia
Which HF drug will increase uric acid/ gout flare up?
Thiazide Diuretics: Hydrocholorthiazide
Loop Diuretics: furosemide
Prototype for thiazide diuretics?
hydrochlorothiazide (HCTZ)
how does hydrochlorothiazide (HCTZ) fxn?
1) reduces BLOOD VOLUME
- works on the distal tubule
- Results in excretion of H20, Na, K+
2) Reduces arterial resistance (over time)
Onset/ duration/ peak for hydrochlorothiazide (HCTZ)
2 hrs., peak 4-6, lasts 12 hours
what is our most WIDELY USED diruetic?
hydrochlorothiazide (HCTZ)
Which HF drug has risk of hyperglycemia in DM patients?
hydrochlorothiazide (HCTZ)
hydrochlorothiazide (HCTZ) is contraindicated with which other allergy
sulfa
prototype for Potassium Sparing Diuretics
spironolactone (Aldactone)
how does spironolactone (Aldactone) fxn?
Competes with aldosterone at receptors in the distal tubule blocking aldosterone
–> fluid lost, K remains
= potassium sparing!
Onset for spironolactone (Aldactone)
Potassium Sparing Diuretic
Aldosterone Receptor Blockers
Takes up to 48 hours to work
Side effects for spironolactone (Aldactone)?
Potassium Sparing Diuretics
Aldosterone Receptor Blockers
- hyperkalemia (high K+)
- Endocrine effects: gynecomastia
Nursing consideration for HYPOkalemia associated with diuretics?
Hypokalemia (Thiazide/Loop) ✔ K levels before admin. Teach high K+ foods Risk for dysrhythmias Risk for digoxin & lithium toxicity
Nursing consideration for HYPERkalemia associated with diuretics? (think about other drugs you would or would not give this with)
✔ K levels before admin.
Typically, don’t admin. with RAAS drugs, K supplements
Why do we check daily wait for HF patient on diuretics
*Patients may be given a ‘sliding scale’ based on daily wt.