Quiz 5 Study Guide: Bone and Joint Flashcards

1
Q

99% of the body’s calcium is stored where?

A

In the Bones

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2
Q

Where is the primary site of Hematopoiesis?

A

Bones

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3
Q

Bones are constantly…

A

Remodeling

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4
Q

Medullary bone resits….

A

Compression forces

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5
Q

Cortical bone is…

A

Thick and resists bending forces

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6
Q

What is a tough fibrous membrane that covers bone surfaces except at joints and is well innervated?

A

Periosteum

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7
Q

What is characteristic of Osteogenesis imperfect?

A

Deficient type 1 collagen (too little bone)
Generalized Osteopenia
-Multiple fractures and bone deformities
- Malformed teeth (dentin deficiency)
Blue Sclera

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8
Q

What is characteristic in an achondroplastic dwarf?

A

Reduced function of growth plates

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9
Q

What is characteristic of Osteopetrosis?

A

Defective osteoclasts

Bone is brittle and too dense

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10
Q

What are examples of acquired diseases of bone?

A
Vitamin Deficiencies (Scurvy or Rickets)
Endocrine Factors (Hyperparathyroidism)
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11
Q

What are specific types of acquired diseases of bone?

A

Osteoporosis -common in elderly and post menopause
Osteomalacia- Vit. D deficiency (Lack normal mineralization usually in the kidney)
Hyperparathyroidism - High Ca++ caused by parathyroid adenoma.

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12
Q

What causes Osteoporosis?

A

Genetic- age, low estrogen, fair hair and skin, tall and thin
Behavior- Inactivity, smoking/alcohol, malnutrition, medication (Chronic Corticosteroids)

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13
Q

What is the burden of osteoporosis?

A

10 million in US (mostly women)

1/3 women > 50 Years old have at least on osteoporotic fracture.

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14
Q

What are disorders of Bone instability?

A

Kyphosis - forward curvature of spine

Scoliosis - Lateral curvature of spine

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15
Q

What are the different type of fractures?

A

Complete
Closed (Underlying tissue intact)
Comminuted-Bone splintered
Displaced

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16
Q

What is osteomyelitis?

A

Inflammation of bone/marrow

17
Q

What are characteristics of Osteomyelitis?

A

Blood born or direct
Trauma from compound fractures
Pyogenic Infections (Staph or Salmonella)
Granulomatous (TB or Fungal)
-Pott disease when TB and in spine
Diabetes due to poor circulation in the extremities
-Chronic can form drainage site and become osteosarcoma

18
Q

Osteoarthritis (OA) is a….

A

Degenerative Joint disease

19
Q

What is characteristic of Osteoarthritis?

A
  • Loss of articular cartilage with secondary changes in bone
  • Presents in some degree in most persons >65 years old
    • symptoms worsen with use
  • Due to wear and tear
  • No inflammatory changes, but degenerative
20
Q

What is characteristic of Rheumatoid Arthritis?

A
  • More systemic and Bilateral
  • Autoimmune = 1% prevalence
  • Most common in caucasians. Not in asians
  • Onset age = 25-50 yrs. 75% female/ can have juvenile RA
  • Joint swelling, pain and tenderness
  • extreme distortion of joints and bone
  • may have fever, weakness, malaise
21
Q

What are other areas affected by Rheumatoid Arthritis?

A

Ulcers
Pulmonary nodules and fibrosis
Carditis and pericarditis
Vasculitis

22
Q

What are other inflammatory Arthritites?

A
Psoriatic Arthritis
Other Autoimmune diseases (Lupus)
Postinfections (e.g. Rheumatic Fever)
Infectious (Staph or Strep)
Gout (Crystalized uric acid)
Lyme Disease (when not treated)
23
Q

What is the primary cause of Gout?

A

Reduced renal excretion of purine (uric acid is break down product)

24
Q

What is the primary treatment for Gout?

A

Allopurinol - Decreases the synthesis of purines.

25
What are the symptoms of Gout?
Hot, swollen, pain in joints Progressive Joint Destruction *gouty top (crystalized aggregates of uric acid)
26
What is pseudo-gout?
Crystal deposits of calcium pyrophosphate
27
What are ganglion cysts?
a cyst resulting from connective tissue around joints | *often painful
28
Where are malignant carcinomas spread to the bone tumors most likely to come from?
``` The lungs Prostate Breast Thyroid Kidneys ```
29
Bone tumors most likely to be seen in maxilla and mandible are?
Osteomas-immature bone Giant Cell Tumor (benign, aggressive) Fibrous Dysplasia (not malignant) Osteosarcoma (adolescents or elderly) Ewing Sarcoma (10-20 year olds; *2nd most frequent after Osteosarcoma)
30
What is an osteosarcoma?
Most frequent form of bone malignancy * adolescent or geriatric patients most likely * usually in long bones or sometime mandible
31
What is an osteochondroma?
Benign tumors of the cartilage: do not see in mandible or maxilla
32
What is a chondrosarcoma?
Malignancy of Cartilage
33
What is Fibrous Dysplasia?
A Benign Medullary bone that does not properly mature *often in jaws
34
What is Ewing Sarcoma?
2nd most frequent Sarcoma after osteosarcoma. *10-20 year olds
35
Where can you see a Giant Cell Tumor?
Mandibular Bone
36
What are the different types of Soft tissue tumors?
Lipomas (Common/usually no tx) Liposarcoma (Malignant) Fibrous Tumors Fibrosarcoma (Malignant neoplasm of fibroblasts) Skeletal Muscle tumor (Rhabdomyomasarcoma) Smooth Muscle tumor (Benign leiomyomas and leiomyosarcomas)