Quiz 5 Study Guide: Bone and Joint Flashcards
99% of the body’s calcium is stored where?
In the Bones
Where is the primary site of Hematopoiesis?
Bones
Bones are constantly…
Remodeling
Medullary bone resits….
Compression forces
Cortical bone is…
Thick and resists bending forces
What is a tough fibrous membrane that covers bone surfaces except at joints and is well innervated?
Periosteum
What is characteristic of Osteogenesis imperfect?
Deficient type 1 collagen (too little bone)
Generalized Osteopenia
-Multiple fractures and bone deformities
- Malformed teeth (dentin deficiency)
Blue Sclera
What is characteristic in an achondroplastic dwarf?
Reduced function of growth plates
What is characteristic of Osteopetrosis?
Defective osteoclasts
Bone is brittle and too dense
What are examples of acquired diseases of bone?
Vitamin Deficiencies (Scurvy or Rickets) Endocrine Factors (Hyperparathyroidism)
What are specific types of acquired diseases of bone?
Osteoporosis -common in elderly and post menopause
Osteomalacia- Vit. D deficiency (Lack normal mineralization usually in the kidney)
Hyperparathyroidism - High Ca++ caused by parathyroid adenoma.
What causes Osteoporosis?
Genetic- age, low estrogen, fair hair and skin, tall and thin
Behavior- Inactivity, smoking/alcohol, malnutrition, medication (Chronic Corticosteroids)
What is the burden of osteoporosis?
10 million in US (mostly women)
1/3 women > 50 Years old have at least on osteoporotic fracture.
What are disorders of Bone instability?
Kyphosis - forward curvature of spine
Scoliosis - Lateral curvature of spine
What are the different type of fractures?
Complete
Closed (Underlying tissue intact)
Comminuted-Bone splintered
Displaced
What is osteomyelitis?
Inflammation of bone/marrow
What are characteristics of Osteomyelitis?
Blood born or direct
Trauma from compound fractures
Pyogenic Infections (Staph or Salmonella)
Granulomatous (TB or Fungal)
-Pott disease when TB and in spine
Diabetes due to poor circulation in the extremities
-Chronic can form drainage site and become osteosarcoma
Osteoarthritis (OA) is a….
Degenerative Joint disease
What is characteristic of Osteoarthritis?
- Loss of articular cartilage with secondary changes in bone
- Presents in some degree in most persons >65 years old
- symptoms worsen with use
- Due to wear and tear
- No inflammatory changes, but degenerative
What is characteristic of Rheumatoid Arthritis?
- More systemic and Bilateral
- Autoimmune = 1% prevalence
- Most common in caucasians. Not in asians
- Onset age = 25-50 yrs. 75% female/ can have juvenile RA
- Joint swelling, pain and tenderness
- extreme distortion of joints and bone
- may have fever, weakness, malaise
What are other areas affected by Rheumatoid Arthritis?
Ulcers
Pulmonary nodules and fibrosis
Carditis and pericarditis
Vasculitis
What are other inflammatory Arthritites?
Psoriatic Arthritis Other Autoimmune diseases (Lupus) Postinfections (e.g. Rheumatic Fever) Infectious (Staph or Strep) Gout (Crystalized uric acid) Lyme Disease (when not treated)
What is the primary cause of Gout?
Reduced renal excretion of purine (uric acid is break down product)
What is the primary treatment for Gout?
Allopurinol - Decreases the synthesis of purines.