Quiz 1-rapidly progressive cresentic glomerular nephritis Flashcards
Type I anti-GBM
devotement of aggression against basement membrane (type II hypersensitivity)E.G. Good pasture’s syndrome
Good pasture’s syndrome
attacks alveolar basement membrane=hemoptysis coughing up blood causing exudates to prevent air exchangeattacks glomerular basement membrane= destruction of tissue around the membranes involves both respirator system and kidneys
CURABLE VIA PLASMAPHERESIS
good pasture’s syndrome
Type II- immune complex deposition
type III hypersensitivity1. systemic lupus erythematosus2. Henoch-Schonlein Purpura
systemic lupus erthyematosus: TMT and survival rate
90% survival rate, corticosteroids and immunosuppressants
systemic lupus erthyematosus
attacks antigens in cell cytoplasmwomen, 20s african descentinvolves htn which may lead to stroke, butterfly rash,
lupus nephritis
involvement of kidneys, vasculitis of cerebral vessels
Henoch-Schonlein purpura
hemorrhagic vasculitis usually in boys around 20s1. abdominal syndrome2. cutaneous syndrome3. articular syndrome4. crescentic glomular nephritis (kidney syndrome)
- abdominal syndrome2. cutaneous syndrome3. articular syndrome
90% survival rate with these syndromes70% with kidney syndrome
Type III - Pauci-immune
most dangerous and characterized by vasculitis and anti-neutrophil pasmocytic auto-antibodieswegener’s granulematosuspolyarteritis nodosaIGA Nephropathy (Berger’s disease)
most common glomerular disease in worldwide
Berger’s disease
patient will die due to renal failure or other secondary complications
wegeners granulematosus
necrotizing vasculitis of upper and lower respiratory tracts and melting of bond on face
wegener’s granulematosus (Type III Pauci immune)
characterized by vasculitis in vessels throughout the body. This can eventually lead to pouching and obstruction of lumen. DOES NOT OCCUR IN LUNGS AND ARCH OF AORTA
polyarteritis nodosa
hematuria following acute respiratory, intestinal or urinary infection. IGA deposits everywhere and if not controlled can manifest to chronic glomerulonephritis
IGA Nephropathy