PSYCHOPHARMACOLOGY - Antidepressants

Question 1

Which drug increases serum levels of
dextromethorphan/Risperdal due to
interactions with CYP2D6 system? (2x)

Answer 1

Fluoxetine

Question 2

Why do SSRIs take time?

Answer 2

Desensitization of presynaptic 5HT1A

receptors

Question 3

Antidepressant with most potent inhibition

of CYP450 2D6?

Answer 3

Fluoxetine

Question 4

Most likely reason for relapse of symptoms
in adolescent with OCD who was previously
stable on 200mg of Fluvoxamine?

Answer 4

Starting nicotine use

Question 5

Patient on paroxetine wants to taper off.
Previous taper attempts failed (dizziness,
fatigue, irritability, paresthesias). Cross
taper to, then discontinue off which
antidepressant?

Answer 5

Fluoxetine

Question 6

Contraindicated antidepressant in patient
with epilepsy due to lower seizure
threshold?

Answer 6

Bupropion

Question 7

Medication that is less effective in children
due to immature brain noradrenergic
pathways?

Answer 7

TCAs