GENETICS Flashcards
Epigenetic modification leading to gene expression?
Acetylation of histones
Phenotype amplification refers to?
An interaction of a particularly vulnerable genetic background with risk-conferring environmental factors.
Ordering genetic testing for
pharmacodynamic factors with medication is promising for?
Identifying risk for rare idiosyncratic
adverse effects
Challenge of using pharmacogenetics in child & adolescent pharmacology?
Small effect sizes of genes related to psychiatric conditions
Genetic principle explaining why Fragile X syndrome gets worse in future generations?
Anticipation
Genetic tests for triplet nucleotide repeats or methylation abnormalities?
FISH
Epigenetic regulation can occur through methylation or?
Histone acetylation
Mapping disease susceptibility genes in a population by identifying two loci in close proximity is?
Linkage disequilibrium
Approach used in searching for genetic variants for early-onset psychosis with DNA samples from a large group of children. Genotypes determined on thousands of SNPs for each sample and data analyzed to find loci that are affected at significant frequency in affected children without psychosis.
Genome-wide association study
Linkage analysis is used to?
Locate a susceptibility gene for a mental illness on a given chromosome
What regulatory mechanism is best
example of epigenetics?
X chromosome inactivation
Multiple studies indicate maternal stress during pregnancy leads to risk of psychiatric illness in offspring through DNA methylation of glucocorticoid genes in what location?
Placenta
What is assessed in Chromosomal
microarray analysis testing in children
diagnosed with Autism?
deletions or duplications of sections of DNA
Child gets up from prone position with
hands, now becoming progressively
weaker, with MRI showing symmetric basal ganglia lesions. Diagnosis?
Mitochondrial Disorder
What happens during gene imprinting?
Genes of paternal or maternal origin are silenced
