proteins II Flashcards
it evaluates degree of intravascular hemolysis (HTR and HDN)
a, hemopexin
b. GC globulin
c. Haptoglobulin
d. ceruloplasmin
haptoglobulin
- a2 glycoprotein
- apr
- it binds free hemoglobin by its chan
- prevents the loss of hgb and its constituent iron into the urine
- evaluate degree intravascular hemolysis (HTR and HDN)
- slightly decreased after blood transfusion
- it is one of the proteins evaluates rheumatic disease
proteins increased in stressful conditions
a, hemopexin
b. GC globulin
c. Haptoglobulin
d. ceruloplasmin
haptoglobulin
- evaluate degree intravascular hemolysis (HTR and HDN)
- slightly decreased after blood transfusion
- it is one of the proteins evaluates rheumatic disease
- increased: STRESSFUL CONDITIONS, MYOGLOBULINURIA
- decreased : INTRAVSCULAR HEMOLYSIS AND HEMOGLOBINURIA
blue color to ptotein
a. ceruloplasmin
b. haptoglobulin
c. alpha 2 microglobulin
d. beta 2 microglobulin
Ceruloplasmin
- copper binding alpha 2 glycoprotein that has enzymatic activities
- synthesized in the liver that has 6-8 atoms attached
- blue color to protein
- marker for Wilson’s disease
kayser fleisher rings
a. ceruloplasmin
b. haptoglobulin
c. alpha 2 microglobulin
d. beta 2 microglobulin
Ceruloplasmin
- marker for Wilson’s disease
- clinical feature of wilson’s disease
- deposition of copper in skin, liver , brain and eye (KAYSER FLEISHER RINGS)
DECREASED: menke’s kinky hair syndrome
a. ceruloplasmin
b. haptoglobulin
c. alpha 2 microglobulin
d. beta 2 microglobulin
ceruloplasmin
- increased : Inflammation, cancer, pregnancy
- decreased: Wilson’s disease , Malnutrition, malabsorption, nephritic disease and Menke’s kinky hair’s syndrome
largest non immunoglobulin protein in plasma
a. ceruloplasmin
b. haptoglobulin
c. alpha 2 microglobulin
d. beta 2 microglobulin
alpha 2 - macroglobulin (AMG)
- largest non immunoglobulin protein in plasma
- found in intravascular spaces
- it inhibits proteases : trypsin, pepsin and plasmin
- increase in Nephrosis (10x) , diabetes and Liver disease
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it forms complex with prostate specific antigen
a. ceruloplasmin
b. haptoglobulin
c. alpha 2 microglobulin
d. beta 2 microglobulin
alpha 2 - macroglobulin (AMG)
- it FORMS COMPLEX with prostate specific antigen
alpha 1 - antichymotrypsis (a1-X)
- BINDS AND ACTIVATES PSA
light chain component of major human leukocyte antigen
a. ceruloplasmin
b. haptoglobulin
c. alpha 2 microglobulin
d. beta 2 microglobulin
beta2 - microglobulin
- lc of major HLA
- found on the surface of all nucleated cells
`- present in high concentration of lymphocytes
Synthesized in the plasma cell
a. ceruloplasmin
b. transferrin
c. immunoglobulin
d. lipoprotein
immunoglobulins
- they are synthesized in the plasma cells
increased : hemochromatosis
a. ceruloplasmin
b. transferrin
c. immunoglobulin
d. lipoprotein
transferrin (siderophilin)
- increased : HEMOCHROMATOSIS (BRONZE SKIN) , IDA
- decreased: Liver disease, MAlnutrition, nephrotic syndrome
major component of beta2 globulin fraction
a. ceruloplasmin
b. transferrin
c. immunoglobulin
d. lipoprotein
transferrin (siderophilin)
- major component of B2 globulin fraction
- negative APR
- transports iron to its storage sites
- prevent loss of iron through the kidneys
in IDA what is the concentration of transferrin
a. increased
b, decreased
in IDA transferrin concentration is NORMAL / INCREASED
- an elevated plasma level appears as “ paraprotein” - PSEUDOPARAPROTEINEMIA in SEVERE IDA
one of the largest proteins in the blood
a. transferrin
b. immunoglobulin
c. fibrinogen
d. lipoprotein
fibrinogen
- one of the largest protein in the blood
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