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kidney function test Flashcards

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1
Q

commonly used to monitor renal function

a. bun
b. creatinine
c. bua
d. gfr

A

creatinine

  • it is not affected by protein diet ; NOT EASILY REMOVED BY DIALYSIS
  • NOT REUSED by body’s metabolism, soley as waste product
  • COMMONLY USED TO MONITOR RENAL FUNCTION; AN INDEX OF OVERALL RENAL FUCNTION
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2
Q

used to evaluate fetal kidney maturity

a. bun
b. creatinine
c. bua
d. gfr

A

creatinine

  • it is not affected by protein diet ; NOT EASILY REMOVED BY DIALYSIS
  • NOT REUSED by body’s metabolism, soley as waste product
  • COMMONLY USED TO MONITOR RENAL FUNCTION; AN INDEX OF OVERALL RENAL FUCNTION
  • used to evaluate fetal kidney maturity
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3
Q

a 24 hour urine sample with _______ of creatinine indicates that some of the urine was probably discarded

a. <0.4 g/ day
b. >10g/day
c. <0.8 g/day
d. >8.0 g/day

A

a 24 hour urine sample with <0.8g/day of creatinine indicates that some of the urine was probably discarded

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4
Q

methods for creatinine that requires large sample in pre incubation

a. Creatinine Aminohydrolase = Ck method
b. creatinase - hydrogen peroxide method
c. folin wu method
d. kinetic jaffe method

A

CREATININE METHODS

  1. ENZYMATIC METHOD
    a. Creatinine aminohydrolase - CK method
    • REQUIRES LARGE SAMPLE IN PRE INCUBATION ; NOT WIDELY USED
      b. Creatinase- hydrogen peroxide method
    • potential to replace Jaffe method (SPECIFIC THAN JAFFE)
  2. Direct Jaffe method
    a. folin wu
    b. llyod or fuller
  3. kinetic jaffe
  4. IDMS
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5
Q

methods for creatinine that is specific and sensitive method

a. Llyod or Fuller’s earth method
b. creatinase - hydrogen peroxide method
c. folin wu method
d. kinetic jaffe method

A

CREATININE METHODS

  1. ENZYMATIC METHOD
    a. Creatinine aminohydrolase - CK method
    b. Creatinase- hydrogen peroxide method’
  2. Direct Jaffe method
    a. folin wu
    • sensitive but NOT SPECIFIC

b. llyod or fuller
SENSITIVE AND SPECIFIC

  1. kinetic jaffe
  2. IDMS
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6
Q

SODIUM ALUMINUM SILICATE

A. Llyod’s reagent
B. Fuller’s earth reagent

A

Direct Jaffe method

a. folin wu
- sensitive but NOT SPECIFIC

b. llyod or fuller
SENSITIVE AND SPECIFIC
adsorbent :
Llyod’s reagent - SODIUM aluminum silicate
Fuller’s earth reagent - aluminum Mg+ silicate (FM)

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7
Q

which of the ff is not decreased in creatinine

a. decreased muscle muscle mass
b. Myasthenia gravis
c. pregnancy
d. advanced and severe ilver disease

A

INCREASED serum creatinine (icmc)

  1. Impaired renal function
  2. Chronic nephritis
  3. Congestive heart failure
  4. muscular disease - MYASTHENIA GRAVIS , MUSCULAR DYSTROPHY

DECREASED (DAPI)

  1. Decreased muscle mass
  2. inadequate urinary protein
  3. pregnancy
  4. advanced and severe liver disease
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8
Q

there is striking BUN level, slowly rising plasma creatinine, anemia and electrolyte imbalance

a. pre renal azotemia
b. post renal azotemia
c. renal azotemia
d. uremia

A

pre renal azotemia
- decreased GFR , urea and creatinine , normal renal function

renal azotemia
- striking BUN level, slowly rising plasma creatinine, anemia and electrolyte imbalance

post renal azotemia
- urea is higher than creatinine

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9
Q

characterized by anemia (normo,normo) , uremic frost, generalized edema, foul breath and sweat in urine like

a. azotemia
b. post renal azotemia
c. uremia

A

uremia

  • marked elevation in plasma urea and other nitrogenous waste products and acidemia and elec balance
  • characterized by anemia (normo,normo) , uremic frost, generalized edema, foul breath and sweat in urine like
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10
Q

conditions that is responsible for changes of Red cell shape with burr cells (echinocytes) and ellipsoidal cellls

a. azotemia
b. post renal azotemia
c. uremia

A

uremia

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11
Q

how many uric acid is excreted daily

a. 1.23 g
b. 1 g
c. 4.1 g
d. 2 g

A

1g

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12
Q

measures the renal plasma flow

a. PAH test
b. PSP test
c. concentration test

A 
III. test measuring tubular dunction
 A. Excretion tests
  1. Para amino hippurate test
   - measures RENAL PLASMA FLOW
    - rv:  600-700mL/ min
  1. Phenolsulfonthalein dye test (PSP)
    - measures EXCRETION OF DYE PROPORTIONAL TO RENAL TUBULAR MASS
    - DOSE : 6MG OF PSP IS ADMINISTERED IV
    - RV: 1200 ML BLOOD FLOW/ MIN
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13
Q

it can detect renal damage that is not yet severe enough to cause elevated plasma urea and creatinine levels

a. psp test
b, concentration test
c. SG
d. osmolality

A

concentration test

  • reflects the function of the collecting tubules and loops of henle
  • assess the quantity of solutes present in urine
  • can detect renal damage that is not yet severe enough
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14
Q

normal ratio of urine osmolality to serum osmolality

a. 20:1
b. 10:1
c. 2:2
d. 1:1

A

1:1

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15
Q

difference between measured and claculated plasma osmolality

a. excretion
b. osmolality
c. osmol gap
d. osmolal gap

A

osmolal gap

  • difference between measured and calculated plasma osmolality
  • > 12 mOsm/kg is significant seen in DKA, drug overdose and renal failure
  • sensitive indicator of alcohol and drug overdose
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clinical chemistry (26 decks)

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