LIPOPROTEINS

Question 1

enzymes that hydrolyzes TAG and CHOLE esters in lpp

a. LPL
b. hepatic lipase
c. LCAT
d. Endothelial lipase

Answer 1

Enzymes that participate in lpp metabolism

Lipoprotein lipase (LPL)

• hydrolyzes TAG and CHOLE esters in lpp
• released of fatty acid and glycerol

Question 2

enzymes that hydrolyzes TAG and phospholipids from HDL

a. LPL
b. hepatic lipase
c. LCAT
d. Endothelial lipase

Answer 2

Enzymes that participate in lpp mertabolism

Hepatic phase

• hydrolyzes TAG and phospholipids FROM HDL
• hydrolyzes lipids ON VLDL and IDL

Endothelial lipase
-hydrolyzes TAG and phospholipids IN HDL

Question 3

major end product from the catabolism of VLDL

a. Chylomicron
b. VLDL
c. HDL
d. LDL

Answer 3

LDL

• major end product from the catabolism of VLDL
• major source of cholesterol for tissues
• most cholesterol rich of lipoprotein most atherogenic

IDL

• product of VLDL catabolism “VLDL REMNANT”
• it is converted to LDL “ subclass of LDL”

Question 4

subclass of LDL

a. HDL
b. Chylomicrons
c. IDL
d. Lp(a)

Answer 4

LDL

• major end product from the catabolism of VLDL
• major source of cholesterol for tissues
• most cholesterol rich of lipoprotein most atherogenic

IDL

• product of VLDL catabolism “VLDL REMNANT”
• it is converted to LDL “ subclass of LDL”

Question 5

reverse cholesterol transport

a. Chylomicron
b. VLDL
c. HDL
d. LDL

Answer 5

HDL

• it transports excess cholesterol from tissues and it to liver (REVERS CHOLESTEROL TRANSPORT)
• HDL2 transports effectively the lipids to the liver and more cardioprotective

Question 6

what is the CDC reference method for HDL

a. liebermann burchardt
b. abell kendal assay
c. precipitation with heparin MnCl2
d. ultarcentrifugation

Answer 6

Hdl

CDC reference method
ultracentrifugation
precipitation with heparin MnCl2
abell kendal assay (3 step method)

Question 7

it is the primary target of cholesterol lowering therapy; PRIMARY MARKER FOR CHD RISK

a. Chylomicron
b. VLDL
c. HDL
d. LDL

Answer 7

LDL

- PRIMARY MARKER FOR CHD RISK

Question 8

increased level may indicate premature coronary heart disease and stroke

a. IDL
b. Lp (a)
c. Beta- VLDL
d. Lp X

Answer 8

Lp(a) / Lipoprotein A

• knows as SINKING PRE-B LIPOPROTEIN
• increased level may indicate PREMATURE CORONARY HEART DISEASE AND STROKE
• independent risk factor for ATHEROSCLEROSIS

Question 9

it is specific and sensitive indicator of cholestasis

a. beta VLDL
b. VLDL
c. LDL
d. Lpp X

Answer 9

Lipoprotein X

• found in OBSTRUCTIVE JAUNDICE AND LCAT DEFICIENCY
• SPECIFIC AND SENSITIVE INDICATOR OF CHOLESTASIS
• Lipid content is mostly PHOSPHOLIPID AND FREE CHOLESTEROL
• contains Apo C and Albumin

Question 10

what abnormal lpp is rich in cholesterol than VLDL

a. Lpp a
b. Lpp X
c. beta vldl
d. IDL

Answer 10

Beta VLDL

• abnormally migrating B-VLDL
• RICH IN CHOLESTEROL THAN VDRL , due to catabolism of VLDL, there is failure to convert VLDL to LDL, causing IDL to accumulate also

Question 11

sample collected using ______ is preferred sample

a. edta
b. sps
c. serum separator tube
d. heparin

Answer 11

sample collected using SERUM SEPARATOR TUBE is preferred sample