kidney function test Flashcards
Functions of the Kidney
- _____________ of waste produccts
- maintenance of __________
- maintenance of _________
- maintenance of __________
- _________ function
function of the kidney
- ELLIMINATION of waste products
- Maintenance of BLOOD VOLUME
- maintenance of ACID BAS EBALANCE
- maintenance of ELECTROLYTE BALANCE
- ENDOCRINE function
is a measure of clearance of normal molecule that are not bound to protein and freely filtered by the glomerulus
a. . creatinine
b. GFR
c. bun
d. nota
glomerular filtration rate
- CLEARANCE of normal molecule
- best overall indicator of the level of kidney function
- GFR decreases by 1.0mL/minute/year after age 20-30 years old
is the removal of substance from plasma into urine over fixed time
a. clearance
b. inulin clearance
c. urea clearance
d. cystatin C
Clearance
- REMOVAL of substance from plasma into urine over fixed time
- represents volume of plasma
- millimeter/ minute
- plasma concentration and clearance is inversely proportional
reference method for clearance
a. creatine clearance
b. inulin clearance
c. urea clearance
d. cystatin C
inulin clearance
- REFERENCE METHOD
- not routinely done because of necessity for continous iv infusom
it provides an estimate of the amount of plasma that must be flowed through the kidney glomeruli/minute
a. creatine clearance
b. inulin clearance
c. urea clearance
d. cystatin C
creatinine clearance
- estimate of the amount of plasma that must be FLOWED through the kidney glomeruli/minute
- EXCELLENT MEASURE OF RENAL FUNCTION
- measure the completeness of 24 hour urine collection
EXCELLENT MEASURE OF RENAL FUNCTION
a. creatine clearance
b. inulin clearance
c. urea clearance
d. cystatin C
creatinine clearance
- estimate of the amount of plasma that must be FLOWED through the kidney glomeruli/minute
- EXCELLENT MEASURE OF RENAL FUNCTION
- measure the completeness of 24 hour urine collection`
it can demonstrate progression of renal disease or response to therapy
a. creatine clearance
b. inulin clearance
c. urea clearance
d. cystatin C
urea clearance
- progression of renal disease or response to therapy
-
increases more rapidly than creatine in the early stages of GFR impairement
a. creatine clearance
b. inulin clearance
c. urea clearance
d. cystatin C
cystatin C
- increases more rapidly than creatine in the early stages of GFR impairement
- advantage : to assess GFR among pediatric, and eldely patients and renal transplant patients
easily removed by dialysis
a. bun
b. ccreatine
c. bua
blood urea nitrogen
- 1st metabolite to elevated in kidney disease
- EASILY REMOVED BY DIALYSIS
- good indicator of nitrogen intake and state of hydration
about ___ of urea is excreted daily in a stable nitrogen balance
a. 90g
b. 15g
c. 25g
d. 60g
blood urea nitrogen
- 1st metabolite to elevated in kidney disease
- EASILY REMOVED BY DIALYSIS
- good indicator of nitrogen intake and state of hydration
- about 25G of urea is excreted daily in a stable nitrogen balance
which of the ff is the direct method
a. hydrolysis of urea by urease
b. coupled urease / glutamate dehydrogenase (GLD)
c. diacteyl monoxime method
d. idms
- chemical method (direct method)
a. DIACETYL MONOXIME METHOD (DAM/ DMM)- ——-> YELLOW DIAZINE DERIVATIVE
- enzymatic method (indirect method)
a. Hydrolysis of urea by urease
b. couple urease/ glutamate dehydrogenase (GLD) method - IDMS - reference method
which of the following not increased in BUN
a. chonic renal disease
b. pregnancy
c. burn
d. dehydration
answer : pregnancy
increased: (chrostreburn hd)
- chronic renal disease
- stress
- burn
- high protein diet
- dehydration
decrease (HIPP)
- hepatic disorder
- impaired absorption (celiac disease)
- poor nutrition
- pregnancy
______and ______ are added to enhance color development of BUN
a. sialic acid
b. saturated picric acid
c. thiosemicarbazide
d. ferric ions
THIOSEMICARBAZIDE AND FERRIC IONS are added to enhance color development of BUN
