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Infectious Disease > Protein Synthesis Inhibitors > Flashcards

Protein Synthesis Inhibitors Flashcards

1
Q

MOA targets

A

50s or 30s

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2
Q

MOR

A

efflux, target site modification, drug inhibition

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3
Q

all are bacteriostatic except

A

aminoglycosides (and some macrolides)

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4
Q

when used?

A

BL allergy/resistance, intracellular pathogen, no cell wall, in combo with BL

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5
Q

which are 30s

A

tetracycline, aminoglycosides

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6
Q

tetracycline drug

A

doxyclycine, “the tick drug”

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7
Q

doxyclycine MOR

A

efflux. also altered binding

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8
Q

doxyclycineMOA

A

reversible 30s bind, block tRNA binding. intracellular, well distributed

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9
Q

doxyclycine spectrum

A

gram +, -, spirochetes, chlamydia

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10
Q

doxyclycine clinical

A

acne, URI, STD, tick, community MRSA

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11
Q

doxyclycine adverse

A

yellow teeth, GI, photosensitivity

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12
Q

aminoglycosides drug

A

gentamicin

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13
Q

gentamicin MOA

A

30s irreversible bind, prevent translocation

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14
Q

gentamicin MOR

A

inactivate enzyme. also efflux and binding site mutation

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15
Q

gentamicin spectrum

A

gram - bacilli (PSEUD), can be used in synergy with enterococci

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16
Q

gentamicin clinical

A

serious gram - infection, enterococcus endocarditis

17
Q

gentamicin adverse

A

EAR?KIDNEY

narrow TI

DRUG MONITOR

18
Q

Macrolides drug

A

Erythromycin, clarithromucin, azythromycin

19
Q

Erythromycin MOA

A

50s, block translocation

20
Q

Erythromycin MOR

A

change target site, also efflux

21
Q

Erythromycin spectrum

A

gram +, Hflu, chlamydia, mycobacterium.

22
Q

Erythromycin Clinical

A

URI, community pneumonia, PCN allergy, campylobacter, ATPYICAL pneumonia, pertussis

23
Q

Erythromycin adverse

A

CYP450 Drugs!! QT elongation

24
Q

Erythromycin usually swapped for

A

Azythro, less effects

25
Q

Lincosamide drug

A

clindamycin

26
Q

clindamycin MOA

A

50 s, block elongation/transpeptidase, inhibit toxin

27
Q

clindamycin MOR

A

change target site, also others

28
Q

clindamycin spectrum

A

gram +/- anaerobes, gram + aerobes

29
Q

clindamycin clinical

A

TSS, anaerobic strep/staph, gram + pen allergy

30
Q

clindamycin adverse

A

Cdif

31
Q

Oxaxolidinone drug

A

linezolid

32
Q

linezolid MOA

A

50s, no initiation

33
Q

linezolid MOR

A

rate

34
Q

linezolid spectrum

A

gram + cocci (resistant)

35
Q

linezolid clincal

A

resistant gram -

36
Q

linezolid adverse

A

thrombocytopenia, serotonin syndrome, peripheral neuropathy

Infectious Disease (29 decks)

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