Beta Lactams: Penicillin

Question 1

MOA for beta lactams

Answer 1

-inhibit cell wall/growth, no peptidoglycan cross links, dysregulated autolysis

Question 2

MOR beta lactams

Answer 2

beta lactamase, alter PBP site, decrease penetration to target site

Question 3

penicillin general info

Answer 3

beta lactam ring, resistance usually beta lactamase, time dependent killing, renal, high tissue distribution

Question 4

penicillin adverse

Answer 4

allergy (IgE or late), also GI, derm, near, hepatitis, renal, heme

Question 5

penicillin drug bugs

Answer 5

narrow, gram +: GAS, GBS, enterococcus, - neisseria meningitis, spirochetes: treponema palliduam, oral anaerobes

Question 6

penicillin drug clinical uses

Answer 6

Pharyngitis, syphilis, dental issues

Question 7

name pf penicillinase resistant drug

Answer 7

oxacillin

Question 8

oxacillin bugs

Answer 8

Narrow. ONLY GRAM +. staph, strep, good for mixed. MSSA

Question 9

Intermediate spectrum pen with no inhibitor

Answer 9

Ampacillin/amoxicillin

Question 10

Amp/Amox bugs

Answer 10

PEN plus enterococcus, LISTERIA,

neg: H flu, e coli, proteus

Question 11

Amp/Amox clinical

Answer 11

Bronchitis, pharyngitis, otis media, dental, meningitis (listeria), bacteremia (enterococcus)

Question 12

oxacillin adverse

Answer 12

intestinal nephritis, increased liver function, neutropenia, rash

Question 13

oxacillin adverse

Answer 13

intestinal nephritis, increased liver function, neutropenia, rash

Question 14

intermediate pen with inhibitor

Answer 14

Amp + surbactam, Amox+ clavulanate (AUGMENTIN)

Question 15

Augmentin bugs

Answer 15

all above plus S AURES, H flu, anaerobes, trip/enterococcus

Question 16

augmentin clinical

Answer 16

abdominal/pelvic, sinusitis, Otis media, skin, DM, community LRI, human bite wounds

Question 17

Broad spectrum plus inhibitor

Answer 17

peperacillin + tazobactam

Question 18

Peperacillin bus

Answer 18

BROAD. special is PSEUDOMONAS

Question 19

oxacillin clinical

Answer 19

MSSA