HIV ART Flashcards

Question 1

Q

5 classes

Answer

A

NRTI, NNRTI, protease inhibitor, integrase inhibitor, entry inhibitor

Question 2

Q

main combo

Answer

A

2NRTI + integrase inhibitor

Question 3

Q

entry inhibitors, general

Answer

A

not used often- resistance

Question 4

Q

when should viral suppression be?

Answer

A

8-16 weeks

Question 5

Q

two entry inhibitors

Answer

A

enfuvirtide, maraviroc

Question 6

Q

enfuvirtide

Answer

A

(entry) bind viral gp41, prevent fusion

Question 7

Q

maraviroc

Answer

A

(entry) bind CCr5, block cell binding

Question 8

Q

NRTI old drugs

Answer

A

toxic - mitochondria, lactic acidosis, peripheral lipoatrophy

Question 9

Q

NRTI drugs

Answer

A

tenofavir, abacovir, lamuidudine/emtrictabine

Question 10

Q

NRTI MOA

Answer

A

Dna chain terminators, convert to triphosphate, stop DNA growth

Question 11

Q

tenofavir,

Answer

A

(NRTI), preferred, Taf> Tdf, nephrotox and bone mineralization

Question 12

Q

lamuidudine/emtrictabine

Answer

A

(NRTI) cytidine, low toxicity

Question 13

Q

abacavir

Answer

A

NRTI, MI and HLA hypersensitivity (9 day post treat)

Question 14

Q

NNRTI drugs

Answer

A

efavirenz , rilpivirine

Question 15

Q

NNRTI MOA

Answer

A

bind and deform active site- direct inhibition

Question 16

Q

NNRTI MOR

Question 17

Q

rilpivirine

Answer

A

NNRTI, take with food, less effective at high viral loads

Question 18

Q

efavirenze

Answer

A

NNTI, adverse: concentrations, nightmares, depression, teratogen

Question 19

Q

protease inhibitor

Answer

A

needs boosters! (inhibit CYP450 and increase drug length)

Question 20

Q

boosters

Answer

A

ritonovir and cobicistant

Question 21

Q

protease inhibitor drugs

Answer

A

atazanavir, darvanir

Question 22

Q

protease inhibitor MOA

Answer

A

block post translational modification of viral proteins, not infectious

Question 23

Q

protease inhibitor MOR

Answer

A

slow, multiple changes needed

Question 24

Q

which drugs are good for non compliant patients?

Answer

A

protease inhibitors!! (slow to resistance)

Question 25

Q

Integrase inhibir drugs

Answer

A

dolutegravir, elvitegravir, bictegravir, raltegravir

Question 26

Q

atazanavir

Answer

A

PI, fat malabsorption and lots of things

Question 27

Q

Darvanir

Answer

A

PI, skin, diarrhea, nausea, hepatotixic

Question 28

Q

I I MOA

Answer

A

block integrase

Question 29

Q

I I MOR

Question 30

Q

firstling integrate

Answer

A

dolutegravir (but teratogen (neural tubes)