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Infectious Disease > HIV ART > Flashcards

HIV ART Flashcards

1
Q

5 classes

A

NRTI, NNRTI, protease inhibitor, integrase inhibitor, entry inhibitor

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2
Q

main combo

A

2NRTI + integrase inhibitor

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3
Q

entry inhibitors, general

A

not used often- resistance

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4
Q

when should viral suppression be?

A

8-16 weeks

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5
Q

two entry inhibitors

A

enfuvirtide, maraviroc

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6
Q

enfuvirtide

A

(entry) bind viral gp41, prevent fusion

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7
Q

maraviroc

A

(entry) bind CCr5, block cell binding

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8
Q

NRTI old drugs

A

toxic - mitochondria, lactic acidosis, peripheral lipoatrophy

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9
Q

NRTI drugs

A

tenofavir, abacovir, lamuidudine/emtrictabine

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10
Q

NRTI MOA

A

Dna chain terminators, convert to triphosphate, stop DNA growth

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11
Q

tenofavir,

A

(NRTI), preferred, Taf> Tdf, nephrotox and bone mineralization

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12
Q

lamuidudine/emtrictabine

A

(NRTI) cytidine, low toxicity

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13
Q

abacavir

A

NRTI, MI and HLA hypersensitivity (9 day post treat)

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14
Q

NNRTI drugs

A

efavirenz , rilpivirine

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15
Q

NNRTI MOA

A

bind and deform active site- direct inhibition

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16
Q

NNRTI MOR

A

EASY

17
Q

rilpivirine

A

NNRTI, take with food, less effective at high viral loads

18
Q

efavirenze

A

NNTI, adverse: concentrations, nightmares, depression, teratogen

19
Q

protease inhibitor

A

needs boosters! (inhibit CYP450 and increase drug length)

20
Q

boosters

A

ritonovir and cobicistant

21
Q

protease inhibitor drugs

A

atazanavir, darvanir

22
Q

protease inhibitor MOA

A

block post translational modification of viral proteins, not infectious

23
Q

protease inhibitor MOR

A

slow, multiple changes needed

24
Q

which drugs are good for non compliant patients?

A

protease inhibitors!! (slow to resistance)

25
Q

Integrase inhibir drugs

A

dolutegravir, elvitegravir, bictegravir, raltegravir

26
Q

atazanavir

A

PI, fat malabsorption and lots of things

27
Q

Darvanir

A

PI, skin, diarrhea, nausea, hepatotixic

28
Q

I I MOA

A

block integrase

29
Q

I I MOR

A

rate

30
Q

firstling integrate

A

dolutegravir (but teratogen (neural tubes)

Infectious Disease (29 decks)

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