antifungals Flashcards
1
Q
antifungal classes
A
plolynes, allymanines, azoles, echinocandins, pyrimidine inhibitors,
2
Q
polyene drugs
A
amphotericin B, Nyastatin
3
Q
pollen drug mechanisms
A
bind ergosterol, create pore
4
Q
amphotericin B
A
broad but toxic. Severe cryptomeningitis
5
Q
Nyastatin
A
mucocutanous candida, topical
6
Q
Alyamines
A
terbinafine
7
Q
terbinafine MOA
A
block squalene epoxidase
8
Q
terbinafine use
A
skin/nail infections (not systemic
9
Q
terbinafine toxic
A
CYP450!! taste and appetite
10
Q
Azoles MOA
A
inhibit ergosterol
11
Q
Azoles adverse
A
CYP450!!
12
Q
fluconazole
A
candida and crypto
13
Q
voriconazole
A
first line aspergillus, but vision, hallucination, rash, QT
14
Q
posaconazole
A
candida, crypto, aspergillus Transplant proph.
15
Q
echinocandin drugs
A
caspofungin
