DNA toxins

Question 1

three drug classes

Answer 1

fluroquins, sulfas, metronidazole

Question 2

all DNA toxins are cidal or static?

Answer 2

bacterocidal

Question 3

Fluroquinole drugs

Answer 3

copro, levo, moxifloxin

Question 4

fluroquinoline MOA

Answer 4

block DNA gyrase/topoisomerase

Question 5

fluroquinoline MOR

Answer 5

efflux, gyrate mutations

Question 6

fluroquinoline spectrums

Answer 6

gram + (levo/mox), gram - (cipro) atypical pneumonia, mening.m mycobacteria, PSEUDO (Cipro)

Question 7

fluroquinoline clinical

Answer 7

cipro: intra abd, UTI, diarrhea. Levo: CAP/UTI, Moxi: CAP

Question 8

fluroquinoline adverse

Answer 8

QT, arthritis, tendonitis

Question 9

sulfonamide drugg

Answer 9

trimethoprim sulfamethozaole

Question 10

sulfonamide MOA

Answer 10

block folic acid synthesis

Question 11

sulfonamide MOR

Answer 11

decrease permeability, enzyme mutation, efflux, PABA

Question 12

sulfonamide spectrum

Answer 12

gram +: MRSA, gram -: eCOLI, parasites, fungi

Question 13

sulfonamide clinical

Answer 13

UTI, com. MRSA, pneumocystis jirouecci

Question 14

metronidazole MOA

Answer 14

direct DNA damage, toxic nitrogen

Question 15

metronidazole spectrum

Answer 15

ANAEROBES: becteroides (-), +Cdif, tricomonas, guardia, aemebis

Question 16

metronidazole clinical

Answer 16

cliff, mixed abdominal

Question 17

metronidazole adverse

Answer 17

GI, neuro (peripheral neuropathy), drug