Antivirals Flashcards
1
Q
influenza drug classes
A
M2 inhibitor, NA inhibitor
2
Q
M2 inhibitor drugs
A
amantadine, rimadine
3
Q
amantadine MOA, MOR, spectrum, adverse
A
increase viral uncoating, inhibit replication. resistance is easy, flu A, TOXIC cns
4
Q
rimadine
A
less toxic then amantadine but otherwise same
5
Q
NA inhibitor drugs
A
oseltamir (tamiflu) and Zanamivir
6
Q
NA inhibitor MOA
A
block release of viral particlse
7
Q
NA inhibitor resistance
A
less
8
Q
Oseltamir adverse
A
GI
9
Q
Zanamivir side effect
A
bronchospasm
10
Q
Acyclovir MOA
A
chain termination of viral DNA
11
Q
Acyclovir MOR
A
decrease viral kinase, alternate binding, (really only in immune suppressed)
12
Q
Acyclovir spectrum
A
Hsv, vzv
13
Q
Acyclovir adverse
A
nephrotoxicity and neurotoxicity (hallucinations)
14
Q
gancyclovir MOA
A
block DNA pol (indirect)
15
Q
gancyclovir MOR
A
CMB UL97 alteration
