Antivirals

Question 1

influenza drug classes

Answer 1

M2 inhibitor, NA inhibitor

Question 2

M2 inhibitor drugs

Answer 2

amantadine, rimadine

Question 3

amantadine MOA, MOR, spectrum, adverse

Answer 3

increase viral uncoating, inhibit replication. resistance is easy, flu A, TOXIC cns

Question 4

rimadine

Answer 4

less toxic then amantadine but otherwise same

Question 5

NA inhibitor drugs

Answer 5

oseltamir (tamiflu) and Zanamivir

Question 6

NA inhibitor MOA

Answer 6

block release of viral particlse

Question 7

NA inhibitor resistance

Answer 7

less

Question 8

Oseltamir adverse

Answer 8

GI

Question 9

Zanamivir side effect

Answer 9

bronchospasm

Question 10

Acyclovir MOA

Answer 10

chain termination of viral DNA

Question 11

Acyclovir MOR

Answer 11

decrease viral kinase, alternate binding, (really only in immune suppressed)

Question 12

Acyclovir spectrum

Answer 12

Hsv, vzv

Question 13

Acyclovir adverse

Answer 13

nephrotoxicity and neurotoxicity (hallucinations)

Question 14

gancyclovir MOA

Answer 14

block DNA pol (indirect)

Question 15

gancyclovir MOR

Answer 15

CMB UL97 alteration

Question 16

gancyclovir Spectrum

Answer 16

CMV

Question 17

gancyclovir adverse

Answer 17

leukopenia, nephrotoxicity

Question 18

foscarnet MOA

Answer 18

direct DNA pol inhibition

Question 19

foscarnet spectrum

Answer 19

CMV/HSV

Question 20

foscarnet clinical

Answer 20

only use in resistant

Question 21

foscarnet adverse

Answer 21

very toxic

Question 22

cidofavir MOA

Answer 22

Direct DNa pol inhibition

Question 23

cidofavir spectrum

Answer 23

• CMV, adenovirus, smallpox

Question 24

cidofavir adverse

Answer 24

MOST TOXIC