Prostate pathology

Question 1

Prostatitis

Answer 1

Dysuria, frequency, urgency, low back pain

Acute: bacteria (E coli)
Chronic: bacterial or abacterial (most common)

Question 2

BPH: characteristic

Answer 2

> 50 yrs of age
Hyperplasia (not hypertrophy) of the prostate gland.
Nodular enlargement of the periurethral (lateral and middle) lobe, which compresses urethra into a vertical slit.

NOT a premalignant lesion

Question 3

BPH: presentation

Answer 3

Increased frequency of urination
Nocturia
Difficulty starting and stopping
Dysuria

Question 4

BPH: complication

Answer 4

Distention, hypertrophy of bladder
hydronephrosis,
UTI

Increased free PSA

Question 5

BPH: treatment

Answer 5

alpha antagonist (terazosin, tamulosin)
finesteride

Question 6

Prostatic adenocarcinoma: characteristic

Answer 6

> 50 years of age
Most often from the posterior lobe (peripheral zone)
Frequently diagnosed by increase in PSA and subsequent needle core biopsy.

Question 7

Prostatic adenocarcinoma: markers

Answer 7

Prostatic acid phosphtase (PAP)
PSA (increased total PSA, low fraction of free PSA)

Osteoblastic met in late stages, low back pain and increase in serum alk phos and PSA.