Menopause Flashcards
1
Q
MOA
A
Decreased estrogen production due to age-linked decline in number of ovarian follicle
2
Q
Onset
A
At 51 years, earlier in smokers
3
Q
Preceding symptoms
A
4-5 years of abn menstrual cycles.
4
Q
Source of estrogen after menopause
A
Source of estrogen (estrone) after menopause becomes peripheral conversion of androgens.
Increased androgens causes hirsutism
5
Q
Best confirmation
A
Increased FSH:
due to loss of freeback for FSH due to low estrogen.
6
Q
Hormonal changes
A
Low estrogen
HIGH HIGH FSH
high LH (no surge)
high GnRH
7
Q
Symptoms
A
HHAVOC: Hirsutism, Hot flashes, Atropy of Vagina Osteoporosis Coronary artery disease
8
Q
If before 40 yrs of age
A
Premature ovarian failure.
