Estrogen

Question 1

Estrogens

Answer 1

17 beta estradiol, estriol, estrone

Question 2

Sources

Answer 2

Ovary: 17beta estradiol
Placent: estriol
Adipose: estrone via aromatization

Question 3

Potency

Answer 3

Estradiol> estrone > estriol

Question 4

Pregnancy

Answer 4

50x increase in estradiol and estrone

1000x increase in estriol (indicator of fetal well-being)

Question 5

Estrogen function

Answer 5

1) development of genitalia and breast, female fat distribution
2) growth of follicle, endometrial proliferation (increase myometrial excitability)
3) upregulation of estrogen, LH, and progesterone receptor; feedback inhibition of FSH and LH, then LH surge
4) stimulation of prolactin secretion but blocks its action at breast
5) Increase transport proteins: high SHBG, high HDL, low LDL

Question 6

FSH affects what cells

Answer 6

Granulosa,
Increases aromatase,
which then converts androstenedione to estrogen

Question 7

LH affects what cell

Answer 7

Theca cells,
Increases desmolase,
which then converts cholesterol to androstenedione