Androgens

Question 1

Androgens

Answer 1

Testosterone
DHT
androstenedione

Question 2

Source

Answer 2

Testes: DHT and testosterone
Adrenal: AnDrostenedione

Question 3

Potency

Answer 3

DHT > testosterone > androstenedione

Question 4

Testosterone function:

Answer 4

1) diff of epididymus, vas deferens, seminal vesicles (internal genitalia, except prostate)
2) growth spurt: penis, seminal vesicles, sperm, muscle, RBC
3) deepening of voice
4) closing of epiphyseal plate (via estrogen converted from testosterone)
5) libido

Question 5

DHT function:

Answer 5

Early: diff of penis, scrotum, prostate
Late: prostate growth, balding, sebaceous gland activity.

Question 6

Testosterone -> DHT

Answer 6

5alpha reductase, which is inhibited by finasteride

Question 7

Testosterone and androstenedione

Answer 7

Both are converted to estrogen by aromatase in adipose tissue and leydig cells.

Aromatase is the key enzyme in the conversion of androgens to estrongen.

Question 8

Exogenous testosterone

Answer 8

Inhibits hypothalamic-pit-gonadal axis;
low intratesticular testosterone, so
low testicular size, so
azoospermia