Ovarian NON-germ cell tumors

Question 1

Ovarian NON-germ cell tumors: types

Answer 1

1) serous cystadenoma
2) serous cystadenocarcinoma
3) mucinous cystadenoma
4) muscinous cystadenocarcinoma
5) Brenner tumor
6) Fibromas
7) Granulosa cell tumor
8) Krukenberg tumor

Question 2

Ovarian NON-germ cell tumors: risk factor and marker

Answer 2

Risk factor: BRCA1,3, HNPCC

CA-125, general ovarian cancer marker,
good for monitoring progress

Question 3

Ovarian NON-germ cell tumors:

Serous cystadenoma

Answer 3

45% of ovarian tumor; benign
frequently bilateral,

filled with fallopian tube like epithelium.

Question 4

Ovarian NON-germ cell tumors:

Serous cystadenocarcinoma

Answer 4

45% of ovarian tumors: malignant
frequently bilateral.

Psamma bodies seen

Question 5

Ovarian NON-germ cell tumors:

Mucinous cystadenoma

Answer 5

Multilocular cyst lined by mucus secreting epithelium
Benign
Intestine-like tissue.

Question 6

Ovarian NON-germ cell tumors:

Mucinous cystadenocarcinoma

Answer 6

Malignant.

Pseudomyxoma peritonei: intraperitoneal accumulation of mucinous material from ovarian or appendiceal tumor.

Question 7

Ovarian NON-germ cell tumors:

Brenner tumor

Answer 7

Benign and unilateral;
Looks like Bladder (with coffee Beans)
Solild tumor pale, yellow tan in cor and appear encapsulated.

Coffee bean nuclei on H&E staining.

Question 8

Ovarian NON-germ cell tumors:

Fibromas

Answer 8

Bundles of spindle shaped fibroblasts

Meig’s syndrome: ovarian fibroma, ascites, and hydrothorax

Pulling sensation in groin

Question 9

Ovarian NON-germ cell tumors:

Granulosa cell tumor

Answer 9

Secretes estrogen; precocious puberty in kinds
Can cause endometrial hyperplasia/carcinoma in adults
Abnormal uterine bleeding

Call-Exner bodies: small follicles filled with eosinophilic secretion.

Question 10

Ovarian NON-germ cell tumors:

Krukenberg tumor

Answer 10

GI malignancy met to ovaries,

causing mucin secreting signet cell adenocarcinoma.