Pharm: anti androgens Flashcards
1
Q
Anti androgens
A
1) finasteride
2) flutamide
3) ketoconazole
4) spironolactone
2
Q
Finasteride
A
5 alpha reductase inhibitor;
low conversion of testosterone to DHT
Useful in BPH
Also promotes hair growth; treat male pattern baldness
“To treat hair balding, give breasts”
3
Q
Flutamide
A
Nonsteroidal competitive inhibitor of androgens at the testosterone receptor.
Used in prostate carcinoma
4
Q
Ketoconazole
A
Inhibit steroid synthesis; inhibits 17, 20 desmolase
5
Q
Spironolactone
A
Inhibit steroid binding
6
Q
Ketoconazole and spironolactone
A
Used to treat polycystic ovarian syndrome to prevent hirsutism
Both have the side effects of gynecomastia and amenorrhea.
