Proliferative and Neoplastic Diseases of the Liver and Biliary Tree Flashcards
does nodular hyperplasia produce clinical signs of disease?
no
who can get nodular hyperplasia?
dogs
what does nodular regeneration arise from?
proliferation of surviving hepatocytes in response to chronic hepatocellular damage
are metastatic tumors or primary tumors more common in the liver?
metastatic
what is the most common primary tumor type in the liver?
epithelial
who does hepatocellular adenoma impact?
young ruminants
older dogs
what are the clinical signs from hepatocellular carcinoma attributed to?
compression, necrosis/hemorrhage
what are some hepatic round cell neoplasms?
lymphoma
histiocytic sarcoma
mast cell tumor
plasmacytoma: rare
what is the most frequent primary hepatic neoplasm in dogs?
hemangiosarcoma
what are some non-neoplastic biliary proliferations?
biliary hyperplasia
cholangiocellular cystadenoma
what is biliary hyperplasia a common response to?
biliary and/or hepatic insults
what is cholangiocellular carcinoma?
malignant neoplasm of biliary epithelium
what is cholangiocellular adenoma?
benign neoplasm of biliary epithelium
what is the gross appearance of cholangiocellular carcinoma?
capsular masses
umbilicated appearance
what can be seen on histology with nodular hyperplasia?
increased proportion of hepatocytes
hepatocytes often vacuolated
what are the most common causes of nodular regeneration?
copper-associated hepatitis
anti-convulsant therapies
how common are neuroendocrine primary liver tumors?
rare
what does hepatocellular adenoma look like on histology?
well-differentiated hepatocytes forming thickened plates
what does hepatocellular carcinoma look like grossly?
solitary, large, well-demarcated with fibrous bands
what is hepatocellular carcinoma like histologically?
irregular hepatocytes forming thick plates
are there portal tracts or central veins in hepatocellular adenoma or carcinoma?
no
what is myelolipoma?
hepatic sarcoma that impacts wild and domestic felids
what types of carcinoma can metastasize to the liver?
pancreatic
intestinal
urothelial
what is a benign neoplasm of biliary epithelium?
cholangiocellular adenoma
what are the five major types of ductal plate malformation?
choledochal cysts
caroli’s syndrome/dissease
polycystic kidney disease
congenital hepatic fibrosis
von meyenburg complexes
what causes paraneoplastic alopecia in cats?
cholangiocellular carcinoma
