Proliferative and Neoplastic Diseases of the Liver and Biliary Tree Flashcards
does nodular hyperplasia produce clinical signs of disease?
no
who can get nodular hyperplasia?
dogs
what does nodular regeneration arise from?
proliferation of surviving hepatocytes in response to chronic hepatocellular damage
are metastatic tumors or primary tumors more common in the liver?
metastatic
what is the most common primary tumor type in the liver?
epithelial
who does hepatocellular adenoma impact?
young ruminants
older dogs
what are the clinical signs from hepatocellular carcinoma attributed to?
compression, necrosis/hemorrhage
what are some hepatic round cell neoplasms?
lymphoma
histiocytic sarcoma
mast cell tumor
plasmacytoma: rare
what is the most frequent primary hepatic neoplasm in dogs?
hemangiosarcoma
what are some non-neoplastic biliary proliferations?
biliary hyperplasia
cholangiocellular cystadenoma
what is biliary hyperplasia a common response to?
biliary and/or hepatic insults
what is cholangiocellular carcinoma?
malignant neoplasm of biliary epithelium
what is cholangiocellular adenoma?
benign neoplasm of biliary epithelium
what is the gross appearance of cholangiocellular carcinoma?
capsular masses
umbilicated appearance
what can be seen on histology with nodular hyperplasia?
increased proportion of hepatocytes
hepatocytes often vacuolated