Proliferative and Neoplastic Diseases of the Liver and Biliary Tree Flashcards

1
Q

does nodular hyperplasia produce clinical signs of disease?

A

no

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2
Q

who can get nodular hyperplasia?

A

dogs

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3
Q

what does nodular regeneration arise from?

A

proliferation of surviving hepatocytes in response to chronic hepatocellular damage

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4
Q

are metastatic tumors or primary tumors more common in the liver?

A

metastatic

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5
Q

what is the most common primary tumor type in the liver?

A

epithelial

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6
Q

who does hepatocellular adenoma impact?

A

young ruminants
older dogs

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7
Q

what are the clinical signs from hepatocellular carcinoma attributed to?

A

compression, necrosis/hemorrhage

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8
Q

what are some hepatic round cell neoplasms?

A

lymphoma
histiocytic sarcoma
mast cell tumor
plasmacytoma: rare

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9
Q

what is the most frequent primary hepatic neoplasm in dogs?

A

hemangiosarcoma

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10
Q

what are some non-neoplastic biliary proliferations?

A

biliary hyperplasia
cholangiocellular cystadenoma

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11
Q

what is biliary hyperplasia a common response to?

A

biliary and/or hepatic insults

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12
Q

what is cholangiocellular carcinoma?

A

malignant neoplasm of biliary epithelium

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13
Q

what is cholangiocellular adenoma?

A

benign neoplasm of biliary epithelium

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14
Q

what is the gross appearance of cholangiocellular carcinoma?

A

capsular masses
umbilicated appearance

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15
Q

what can be seen on histology with nodular hyperplasia?

A

increased proportion of hepatocytes
hepatocytes often vacuolated

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16
Q

what are the most common causes of nodular regeneration?

A

copper-associated hepatitis
anti-convulsant therapies

17
Q

how common are neuroendocrine primary liver tumors?

A

rare

18
Q

what does hepatocellular adenoma look like on histology?

A

well-differentiated hepatocytes forming thickened plates

19
Q

what does hepatocellular carcinoma look like grossly?

A

solitary, large, well-demarcated with fibrous bands

20
Q

what is hepatocellular carcinoma like histologically?

A

irregular hepatocytes forming thick plates

21
Q

are there portal tracts or central veins in hepatocellular adenoma or carcinoma?

A

no

22
Q

what is myelolipoma?

A

hepatic sarcoma that impacts wild and domestic felids

23
Q

what types of carcinoma can metastasize to the liver?

A

pancreatic
intestinal
urothelial

24
Q

what is a benign neoplasm of biliary epithelium?

A

cholangiocellular adenoma

25
Q

what are the five major types of ductal plate malformation?

A

choledochal cysts
caroli’s syndrome/dissease
polycystic kidney disease
congenital hepatic fibrosis
von meyenburg complexes

26
Q

what causes paraneoplastic alopecia in cats?

A

cholangiocellular carcinoma