Prochorperazine

Question 1

What type of drug is stemetil?

Answer 1

Phenothiazine antiemetic

Question 2

Stemetil acts on several neurotransmitter systems. What are they?

Answer 2

1. Antidopamine action
2. Alpha-adrenergic antagonism
3. Potentials not-adrenaline
4. Weak anticholingeric and antihistamine effects
5. Weak seretonin antagonism

Question 3

What is the indication for stemetil?

Answer 3

For the treatment (only) of nausea and vomiting from a variety of vestibular causes including: motion sickness, migraine, vertigo, and labyrinthitis

Question 4

Stemetil adversely effects all body systems. What are those effects?

Answer 4

Gastro: constipation and dry mouth

Nervous system: drowsiness and extrapyrimidial symptoms

Cardio: hypotension, ECG changes (QT prolongation)

Respiratory: respiratory depression

Question 5

What are the 7 contraindications of stemetil?

Answer 5

1. KSAR to phenothiazines
2. CNS depression
3. Shock from any cause or circulatory compromise
4. Pregnancy
5. < 18 years
6. Conjunction with IV amioderone
7. Previous oral prochloroerazine in last 8 hours

Question 6

What are the 5 precautions of stemetil?

Answer 6

1. Renal dysfunction
2. Parkinson’s
3. Myasthenia gravis
4. Epilepsy
5. Elderly. Increased chance of dystonic reactions

Question 7

What is the dose of stemetil?

Answer 7

12.5mg deep IMI

Question 8

What is the special note with stemetil?

Answer 8

Pts should be TX due to extensive adverse effect profile