primary sclerosing cholangitis Flashcards
1
Q
what
A
condition where the intrahepatic or extrahepatic ducts become strictured and fibrotic
obstruction to flow of bile
2
Q
established association with…
A
ulcerative colitis
3
Q
risk factors
A
male
30-40yrs
UC
FHx
4
Q
presentation
A
jaundice chronic RUQ pain pruritus fatigue hepatomegaly
5
Q
LFT results
A
alkaline phosphatatse most derranged LFT and may be only abnormalityat first
6
Q
autoantibodies
A
antineutrphil cytoplasmic antibody
ANA
anticardiolipin antibodies
7
Q
diagnosis
A
MRCP
Magnetic resonance cholangiopancreatogrophy
8
Q
associations + complications
A
acute bacterial cholangitis cholangiocarcinoma colorectal cancer cirrhosis liver failure biliary strictures fat soluble vit deficiencies
9
Q
Mx
A
liver transplant
ERCP
colestyramine
10
Q
ERCP
A
endoscopic retrograde cholangio-pancreatography
inject contrast + see strictures then dilate/stent
11
Q
colestyramine
A
bile acid sequestration
binds to bile acids to prevent absoprtion in gut
(helps pruritus due to raised bile acids)
