c.diff Flashcards
1
Q
what
A
gram + rod
produces exotoxin which causes intestinal damage –> pseudomembranous coloitis
2
Q
risk factors
A
clindamycin
cephalosporins
PPIs
3
Q
features
A
diarrhoea
abdo pain
raised WCC
4
Q
Mild
A
normal WCC
5
Q
moderate
A
inc WCC <15
3-5 loose stools per fay
6
Q
severe
A
Inc WCC>15
or raised creatinine
or fever >38.5.
or evidence of severe colitis
7
Q
life threatening
A
hypotension
partial or complete ileus
toxic megacolon
CT evidence severe disease
8
Q
diagnosis
A
C difficile toxin in stool
9
Q
Mx - 1st episode
A
oral vancomycin 10days
- oral fidaxomicin
- oral vancomyin +/- IV metronidazole
10
Q
Mx - recurrent infection
A
within 12wks - oral fidaxomicin
after 12wks: oral vancomycin or fidaxomicin
11
Q
Mx - life-threatening infection
A
oral vancomycin + IV metronidazole
