primary biliary cholangitis Flashcards
1
Q
typically seen in
A
middle ages females
2
Q
what happens
A
interlobular bile ducts become damaged by a chronic inflammatory process
causing progressive cholestasis, which may progress to cirrhosis
3
Q
classic presentation
A
itching in a middle aged woman
4
Q
assocs
A
sjogren’s
rheumatoid arthritis
systemic sclerosis
thyroid disease
5
Q
clinical features
A
fatigue prutitis cholestatic jaundice hyperpigmentation clubbing hepatosplenomegaly
6
Q
Dx - immunology
A
anti-mitochondrial antibodies M2 subtype
smooth muscle antibodies
raised IgM
7
Q
Dx- imaging
A
required before diagnosis to exclude extrahepatic biliary obstruction
usually RUQ USS or MRCP
8
Q
Mx - 1st line
A
ursodeoxycholic acid
9
Q
Mx for itching
A
cholestyramine
10
Q
complications
A
cirrhosis –> PRTL HTN –> ascites, varices
otseomalacia, osteoporosis
hepatocellular carcinoma
