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GI > hepatitis > Flashcards

hepatitis Flashcards

1
Q

causes

A 
alcoholic hepatitis
NAFLD
viral 
autoimmune 
drug induced e.g. paracetomal overdose
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2
Q

presentation

A 
abdo pain 
fatigue 
pruritis
myalgia 
N+V
jaundice
fever (if viral)
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3
Q

typical LFT findings

A

raised transaminases

raised bilirubin

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4
Q

hepatitis A - route of transmission

A

faecal-oral route

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5
Q

hepatitis A - presentation

A 
nausea + vomiting 
anorexia
jaundice 
dark urine + pale stools 
hepatomegaly
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6
Q

hepatitis A - clinical course

A

resolves w/o treatment in ~1-3mo

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7
Q

hepatitis A - Mx

A

analgesia

vaccination for prevention

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8
Q

hepatitis A - type of virus

A

RNA

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9
Q

hepatitis B - type of virus

A

DNA virus

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10
Q

hepatitis B - route of transmission

A

direct contact with blood/bodily fluid

sex
sharing needles
vertical transmission

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11
Q

hepatitis B - clinical course

A

most people fully recover within 2mo

10% go on to become chronic hepB carriers

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12
Q

hepatitis B viral markers - surface antigen (HBsAg)

A

indicates active infection

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13
Q

hepatitis B viral markers - HBeAg

A

E antigen

marker of viral replication, implies high infectivity

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14
Q

hepatitis B viral markers - HBcAb

A

core antibodies

implies past or current infection

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15
Q

hepatitis B viral markers - HBsAb

A

surface antibody

implies vaccination or past or current infection

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16
Q

hepatitis B viral markers - HBV DNA

A

direct count of viral load

17
Q

hepatitis B screening: previous infection

A

HBcAb

18
Q

hep B screening - active infection

A

HBsAg

19
Q

how can HBcAb differentiate between acute, chronic and past infections

A

IgM implies active infection: high titre if acute and low titre if chronic

IgG indicates past infection where HBsAg is negative

20
Q

hep B vaccination

A

test for HBsAb to confirm response

3 doses

included in 6in1

21
Q

hep B management

A
  • low threshold for screening those at high risk
  • screen for other blood borne viruses and STDs
  • notify public health
  • antiviral medication
22
Q

Hep C - virus type

A

RNA virus

23
Q

Hep C - route of transmission

A

blood and bodily fluids

24
Q

Hep C - vaccination

A

none available

25
Q

Hep C - disease course

A

1 in 4 make full recovery

3 in 4 become chronic

26
Q

Hep C - complications

A

liver chirrosis

hepatocellular carcinoma

27
Q

Hep C - testing

A

Hep C antibody = screening test

HCV RNA to confirm diagnosis, calculate viral load and assess genotupe

28
Q

Hep C - Mx

A

direct acting antivirals

29
Q

Hep D - virus

A

RNA virus

can only survive in patients with HBV

30
Q

hep E - virus type

A

RNA

31
Q

hep E - route of transmission

A

faecal oral route

32
Q

hep E - clinical course

A

usually produces mild illness + is cleared in a month without treatment needed

rarely progresses to chronic (more so in immunocompromised)

GI (45 decks)

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