autoimmune hepatitis Flashcards
1
Q
assoc with
A
genetic predisposition
viral infection
2
Q
what happens
A
T cell-mediated response against liver cells
3
Q
2 types
A
- adult onset
2. children
4
Q
T1 typically affects..
A
women in late 40s/50s
5
Q
T1 presentation
A
around/after menopause
fatigue
features liver disease
6
Q
T2 presentation
A
teenagers/early 20s with acute hepatitis
high transaminases + jaundice
7
Q
Investigation findings
A
raised transaminases
raised IgG levels
8
Q
type 1 autoantibodies
A
anti-nuclear antibodies
anti-smooth muscle antibodies (anti-actin)
anti-soluble liver antigen
9
Q
t2 autoantibodies
A
anti-liver kidney microsomes 1
anti-liver cytosol antigen type 1
10
Q
diagnosis confirmation
A
liver biopsy
11
Q
Mx
A
high dose steroids (prednisolone) tapered over time as other immunosuppresents (azathioprine) are introduced
