primary biliary cirrhosis Flashcards
1
Q
what is 1ry biliary cirrhosis
A
condition where immune system attacks small bile ducts within live r
2
Q
what happens
A
obstruction of outflow of bile (cholestasis)
back pressure of bile obstruction ultimately leads to fibrosis, scarring and liver failure
3
Q
presentation
A
fatigue pruritus GI disturbance jaundice pale stools xanthoma xanthelasma signs of cirrhosis
4
Q
associations
A
middle aged women
other autoimmune conditions
rheumatoid conditins
5
Q
diagnosis
A
LFTs
autoantibodies
liver biopsy
6
Q
LFT findings
A
alkaline phosophhatase is first enzyme to be raised
other enzymes and bilirubin in later disease
7
Q
autoantibodies
A
anti-mitochondrial antibodies
anti-nuclear antibodies
8
Q
treatment
A
ursodeoxycholic acid - reduce cholesterol absioprtion
colestyramine
9
Q
important end results of disease
A
advanced liver cirrhosis
portal hypertension
