inflammatory bowel disease Flashcards
features of Crohn’s
No blood or mucus entire GIR skip lesions terminal ileum most affected transmural smoking is risk factor weight loss strictures fistulas
UC features (CLOSEUP)
cont inflammation limited to colon + rectum only superficial mucosa smoking is protective excrete blood+mucous use aminosalicytes primary scelrosing cholangitis
presentation
diarrhoea
abdo pain
passing blood
weight loss
testing
routine bloods
CRP
faecal calprotectin
endoscopy with biopsy
diagnosis using
endoscopy with biopsy
Crohns Mx: inducing remission
- steroids
if they dont work consider immunosuppresent
- azathioprine
- mercaptopuring
- methotrexate
Crohns Mx: maintainign remission
- azathioprine, mercaptopurine
alternatives
- methotrexate
- infliximab
Crohns Mx: surgery
if disease only affects distal ileum can resect it
can be used to treat secondary strictures and fistulas
UC Mx: inducing remission in mild-mod disease
- aminosalicylate
2. corticosteroid
UC Mx: inducing remission in severe disease
- IV corticosteroids
2. IV ciclosporin
UC Mx: maintaining remission
aminosalicylate
azathioprine
mercaptopurine
UC Mx - surgery
can remove colon + rectum (panproctocolectomy) and leave ileostomy or Jpouch
UC flare up: severe
passing >6 stool per day containing blood
systemic disturbance e.g. fever
