Primary ovarian failure

Question 1

describe it

Answer 1

menopause <40years, characterised by hypergonadotrophic hypogonadism

Question 2

presentation?

Answer 2

early onset of menopausal symptoms

Question 3

aetiology?

Answer 3

• idiopathic - 50% of cases
• iatrogenic
  
  • chemo, radiotherapy, surgery
• auto-immune
• genetic
  
  • +ve FH, Turner’s
• infections
  
  • mumps, CMV, TB

Question 4

diagnosis?

Answer 4

typical symptoms + raised FSH on 2 consecutive occasions

Question 5

complications?

Answer 5

linked to lack of oestrogen. higher risk of:

• CVD
• stroke
• osteoporosis

Question 6

Mx?

Answer 6

HRT until age of normal menopause

options

• traditional HRT
• COCP

Question 7

what risk does HRT confer over COCP?

Answer 7

increased risk of VTE, however this is reduced w transdermal patches