Ovarian cancer

Question 1

epidemiology?

Answer 1

• elderly women
  
  • highest incidence in 80-84
• most common gynae malignancy

Question 2

Risk factors?

Answer 2

• Age
• BRCA1&2
• Lynch Syndrome
• obesity
• smoking
• More ovulations= higher risk:
  
  • no pregnancies
  • early menarche/late menopause

Question 3

pathology?

Answer 3

majority are epithelial cell adenocarcinoma (mucinous, serous)

Question 4

Presentation?

Answer 4

v non-specific:

• bloating
• early satiety
• pelvic pain
• urinary symptoms
• wt loss

Question 5

Ix?

Answer 5

• CA-125 blood test
• pelvic USS if >35
• staging MRI pelvic /CT chest abdo pelvis

Question 6

staging?

Answer 6

FIGO staging:

stage 1: only in ovary

stage 2: out of ovary but inside pelvis

stage 3: out of pelvis but inside abdo

stage 4: spread outside abdo (distant mets)

Question 7

Mx?

Answer 7

• surgery
  
  • hysterectomy + BSO + omentectomy
• chemotherapy