Prelim | Stomach and Pancreas Flashcards
J-shaped enlargement of the GI tract directly inferior to the diaphragm in the abdomen
Stomach
Most distensible part of the GI tract
Stomach
The stomach connects the (1) and the (2)
- esophagus
- duodenum
Functions as mixing chamber and holding reservoir
Stomach
The stomach produces about — of gastric juice
2000-3000 mL
Measurement of the stomach
About 12inches long and 6 inches across
Stomach functions
- Mixes saliva, food, and gastric juice to form chyme.
- Serves as reservoir for food before release into SI.
- Secretes gastric juice, which contains HCI, pepsin, intrinsic factor, and gastric lipase.
- Secretes gastrin into blood
Kills bacteria and denatures protein
Hydrochloric acid (HCl)
Begins the digestion of proteins
Pepsin
Aids absorption of vitamin B12
Intrinsic factors
Aids digestion of triglycerides
Gastric lipase
Also known as heartburn
GERD: gastro esophageal reflex disease
Main regions of the stomach
- Cardia
- Fundus
- Body
- Pyloric Part
Topmost part of the stomach
Fundus
Part of the stomach where it connects with the esophagus
Cardia
Bolus when it reaches the stomach
Chyme
Divisions of the pyloric part
- Pyloric antrum
- Prloric canal
- Pyloric sphincter
Phenomenon that happens once the food particles in chyme are small enough that they can pass through the pyloric sphincter
Gastric emptying
Controls passage of food from stomach to small intestine; constricts and opens when digested food is ready to go down to the SI
Pyloric sphincter
Increases the surface area of your stomach
Rugae
Greater vs lesser curvaturte of the stomach
Greater:
- convex lateral border
- connects greater omentum to stomach
Lesser:
- concave medial border
- connects stomach to liver
Internal anatomy of the stomach
- Rugae
- Lesser and greater curvature
- Incisura angularis
- Incisura cardialis
- Fornix gastricus
Incisura angularis vs incisura cardialis
Incisura angularis: Small anatomical notch found on the lesser curvature
Incisura cardialis: Small anatomical notch between the esophagus and fundus
Arch-shaped superior margin of fundus
Fornix gastricus
Inner most layer of stomach is (1) layer, followed by (2) , then (3)
- oblique
- circular
- longitudinal
Cells present in the mucosa of the stomach
- Surface mucous cells and mucous neck cells
- Parietal cells
- Chief cells
- G cells
Medical term for vomiting
Emesis
Function of surface mucous cells and mucous neck cells
Secretes mucus and absorption
Function of parietal cells
Secrete intrinsic factor and hydrochloric acid
Kills microbes in food; denatures proteins; converts pepsinogen into pepsin.
Hydrochloric acid
Pepsin (activated form) breaks down proteins into peptides
Pepsinogen
Function of the chief cells
Secrete pepsinogen and gastric lipase (Proteins)
Splits triglycerides into fatty acids and monoglycerides.
Gastric lipase
Function of the G cells
Secrete gastrin
Example of foods with protein
Beans, cheese, nuts, egg, white meat
Example of foods rich in triglyceride
Oily foods, red meat, chicken skin, egg yolk, butter
Within — after eating a meal, the stomach has emptied its contents into the duodenum
2 to 4 hours
A secretion from chief cells that splits triglycerides into fatty acids and monoglycerides
Gastric lipase
This type of hormone is released in the stomach
Gastric hormone
Structure where mixing waves (gentle peristaltic movements) occur
Muscularis
Structure that opens to
permit passage of chyme into duodenum.
Pyloric sphincter
Peristaltic contractions of the smooth muscle from the fundus towards the contracted pylorus
Propulsion
Reduction in size of the food particles by churning in the antrum
Grinding
Grind particles smaller than (1) in diameter can pass through the contracted (2)
- 2mm
- pylorus
The rest of the bolus is pushed back towards the body of the stomach for further M and C digestion
Retropulsion
Sequence 1 (propulsion) and 2 (grinding) are repeated until the food particles are small enough to pass through the contracted pylorus (gastric emptying)
Retropulsion
All chyme not pushed through the pylorus during the active digestion process will be swept into the duodenum by the relaced pylorus
Peristaltic contraction
The stomach only digests (1) and (2)
- Protein
- Triglycerides
Food rich in — are digested the fastest, and spend lesat time in the stomach
Carbohydrates
Foods rich in — spend longer in the stomach
protein
Retroperitoneal organ
Pancreas
Measurement of pancreas
12-15cm (5-6”) long and
2.5cm (1”) thick
Location of the pancreas in relation to other organs
Posterior to the greater curvature of the stomach
Parts of the pancreas
Head
Body
Tail
Largest part of the pancreas
Head
Expanded portion of the pancreas near the curve of the duodenum
Head
How much pancreatic juices are produced daily?
1200-1500 ml
Main function of the pancreas
Secrete pancreatic juices
2 ducts of the pancreas
- Pancreatic Duct (Duct of Wirsung)
- Accessort Duct (Duct of Santorini)
Larger of the two pancreatic ducts
Pancreatic Duct (Duct of Wirsung)
Found where the common hepatic duct and main pancreatic duct is merged
Hepatopancreatic ampulla/ Ampulla of Vater
The ampulla of vater opens on an elevation of the duodenal mucosa known as —
Major duodenal papilla
The passage of pancreatic juice and bile through the hepatopancreatic ampulla into the duodenum is regulated by a mass of smooth muscle surrounding the ampulla known as —
Sphincter of the hepatopancreatic ampulla/ Sphincter of Oddi
What composes of the pancreatic duct (duct of wirsung)?
- Hepatopancreatic ampulla/ Ampulla of vater
- Major duodenal papilla
- Sphincter of the hepatopancreatic ampulla (Sphincter of Oddi)
2 types of cells in the pancreas
Acini
Pancreatic islets / Islets of Langerhans
Cells that comprises 99% of the pancreas
Acini
Cells that comprises 1% of the pancreas
Pancreatic islets / Islets of Langerhans
What do acini cells prduce?
Fluid and digestive enzymes
Digestive enzymes in pancreatic juices produced by acini cells
- Sodium bicarbonate
- Pancreatic amylase
- Trypsin, chymotrypsin, carboxypeptidase, elastase
- Ribonuclease
- Deoxyribuclease
An alkaline digestive ezyme that helps buffer acidity of the chyme
Sodium bicarbonate
Digestive enzyme that digests starch
Pancreatic amylase
Digestive enzyme that digests protein
Trypsin, chymotrypsin, carboxypeptidase, elastase
Digestive enzyme tht digests triglycerides/ fats
Pancreatic lipase
Digestive enzyme tht digests DNA
Deoxyribuclease
Digestive enzyme tht digests RNA
Ribonuclease
Hormones secreted by the pancreatic islet
- Glucagon
- Insulin
- Somatostasin
- Pancreatic polypeptide
Hormone from pancreas that increases glucose levels
Glucagon
Hormone from pancreas that decreases sugar levels
Insulin
Hormone from pancreas that inhibits the production of glucagon or insulin
Somatostatin and pancreatic polypeptide