Prelim | Liver, Gallbladder, & Biliary Tree Flashcards
Heaviest gland
Liver
Weight of the liver
1.4 kg
Second largest organ
Liver
Location of the liver
Inferior to the diaphragm
2 lobes of the liver
Right lobe (larger)
Left lobe
Left lobe of the liver consists of
quadrate lobe
caudate lobe
Separates right lobe and left lobe of the liver
Falciform Ligament
Quadrate vs caudate lobe
Quadrate: Inferior
Caudate: Posterior
Ligament that divides the right lobe of liver from the diaphragm
Coronary ligament
Ligament that divides the left lobe of liver from the diaphragm
Left triangular ligament
Ligament that is the remnant of your umbilicus (umbilical cord)
ligamentum teres hepatis (round ligament)
Components of the liver
- Hepatocytes
- Hepatic laminae
- Bile canaliculi
- Hepatic sinusoids
- Stellate reticuloendothelial (Kupffer) cells
Functional cell of the liver
Hepatocytes
How much of the liver’s volume do the hepatocytes comprise?
80%
Hepatocytes are — sided cells in the liver
5-12
Plate of hepatocytes; group of hepatocytes
Hepatic laminae
Major function of hepatocytes
Produces bile (helps for chemical digestion)
Blood capillaries where blood flows for the liver to absorb oxygen
Hepatic sinusoids
Destroy worn-out white and red blood cells
Stellate reticuloendothelial cells/ Kupffer cells
Hepatic sinusoids converge and deliver blood into a —
central vein
PORTAL of TRIAD consists of
- Bile duct
- Hepatic artery
- Hepatic vein
Hepatic vein vs hepatic artery
Hepatic artery: Red (Oxygenated blood)
Hepatic vein: Blue (Deoxygenated blood)
*Bile duct: doesn’t have a color
ANATOMICAL and FUNCTIONAL units of the liver
- Hepatic lobule
- Portal lobule
- Hepatic acinus
Functional unit of the liver
Hepatic lobule
Shapes of the liver’s anatomical and functional units
- Hepatic lobule: Hexagon
- Portal lobule: Triangle
- Hepatic acinus: Oval
Unit of the liver that has an exocrine function (secretes bile)
Portal lobule
Most preferred functional and structural unit of the liver
Hepatic acinus
Cells in zone 1 of the liver (closest to the branches of the portal triad)
- First to receive oxygen, nutrients, and toxins
- First to take up glucose
- Last one to die and first to regenerate
Cells in the zone 2 of the liver
Intermediate
Cells in zone 3 of the liver (farthest from the branches of the portal triad)
- Last to show obstruction or exposure to toxins
- First to show evidence of fat accumulation
BLOOD SUPPLY of the liver
Hepatic artery (O) and hepatic portal vein (D) –>
Hepatic sinusoids –>
Central vein –>
Hepatic vein –>
Inferior vena cava –>
Right atrium of heart
HHCHIR
Oxygenated blood supplies oxygen through hepatic artery; deoxygenated blood supplies — to the liver through hepatic vein
nutrients
Shape of the gallbladder
Pear
Location of the gallbladder
Posterior to the liver
Measurement of the gallbladder
7-10cm (3-4”) long
Parts of the gallbladder
- fundus
- body
- neck
Where is the neck of the gallbladder connected to?
Cystic duct
Function of the gallbladder
Store and concentrate bile (until it is needed by the duodenum)
In the gallbladder, this is absorbed to make concentrated bile
water (and ions)
Layers of the gallbladder
- Mucosa
- Muscularis
- Perimuscularis
- Serosa
The (1) of the gallbladder consists of (2) arranged in rugae resembling those of the stomach.
- mucosa
- simple columnar epithelium
What layer does the wall of the gallbladder lack?
Submucosa
BILIARY TREE consists of
- R & L hepatic duct
- Common hepatic duct
- Cystic duct
- Common bile duct
- Pancreatic duct
- Ampulla of Vater
Storage of bile from the liver to gallbladder
- Hepatocyte
- Bile canaliculi
- Bile ductules
- Bile ducts
- R & L Hepatic ducts
- Common hepatic duct
- Cystic duct
- Gallbladder
HBBBHCCG
Release of bile from the gallbladder to SI
- Gallbladder
- Cystic duct
- Common bile duct
- Pancreatic duct
- Ampullar of Vater
- Sphincter of Oddi
- Duodenum
GCC PASD
Process of breaking down large lipid to small lipid (fats)
Emulsification
Done so that pancreatic lipase may digest fat
Emulsification
Function of the bile salts
Emulsification and absorption of lipids
How much bile is secreted per day?
800-1000 ml
Color of bile
Yellow, brownish, or olive-green
pH of bile
7.6-8.6
Components of bile
- Water
- Bile salts
- Cholesterol
- Phospholipid (lecithin)
- Bile pigments
- Several ions
BB ChoPho Se Water
FUNCTION OF LIVER, GALLBLADDER, AND BILIARY TREE
- carbohydrate metabolism
- lipid metabolism
- protein metabolism
- processing of drugs and hormones
- excretion of bilirubin
- synthesis of bile ducts
- storage
- phagocytosis
- activation of vitamin D
MAPS SEP