PoxViruses Flashcards
resistance of poxvirus
High (in scabs)
what are called the poxvirus intracytoplasmic acidophilic inclusion bodies in mammals
Guarnieri body
what are called the poxvirus intracytoplasmic acidophilic inclusion bodies in birds
Bollinger body
Which poxvirus genus is zoonotic
Orthopox
Parapox
Parapoxvirus genus
Bovine papular stomatitis, contagious pustular dermatitis, pseudocowpox, seal pox
PoxVirus pathogenesis
aerogenic, PO, contact, arthropods
Primary rep locally
1. stadium erythematosum (reddened)
2. stadium papulosum (proliferatio, grey nodule)
3. stadium vesiculosum (cell necrosis, vesicle)
4. stadium pustulosum (pus)
5. stadium crustosum (dry crust)
6. stadium decrustationis (crust peel off)
7. recovery (with or without scar)
which pox virus does not give a life long immunity?
Parapoxvirus
PoxVirus vaccine
live virus vaccine
attenuated poxvirus vaccine is against which disease
myxomatosis
cowpox causative agent
cowpox virus
cowpox carriers
rodents (25% seropositive)
cowpox route of infection
contact, wounds
cowpox epizootiology
rarely in cattle
entire stock is affected
immunity for years
zoonotic
from cattle to rat
cowpox CS
mild fever, papules at inf. site
Rarely generalized
Haemorrhagic, red/black pustules, papules, (only rarely vesicles): udder, mouth, scrotal skin
not often generalized
Cowpox recovery time
approx. 1 month
longer in poor hygiene conditions
cow pox differential
Herpes mamillitis
cowpox in other animals
rodents: subclinical, around the mouth
feline: asymptomatic or legs, upper resp symptoms
Hu: milking nodules on hands (immune suppresed can become generalized)
elephant, seal: generalized
smallpox infect naturally
only people
Variola major variants
Skin changes, generalized disease: 45% mortality,
The haemorrhagic form: 100% mortality
variola higher mortality in which age group
young
variola vaccination in 1700s
with cowpox, farmers & milkmaids suffered less from smallpox
smallpox occurence
Earth is free from the 8th of May 1980
Monkeypox occurence
endemic in central and west africa
monkeypox occurence
endemic in central and west africa
how lethal is monkeypox in humans
used to be 30% now lower due to small pox vaccination
2022 monkeypox pandemic
almost only among bi- & homo-sexuals
Pseudocowpox’s virus from which genus
parapox genus
pseudocowpox infects
cattle & humans: Zoonotic
pseudocowpox in cows
mild, disease on udder and teat
introduction of infected animals, infection by contact (hands, milking cups)
pseudocowpox symptoms
lesions on udder and teat
serous exudate on surface of papules
incubation 1 week
short immunity = recurrent disease
Bovine papular stomatitis infects what age group
mostly calves under 1 year old, but occurs at any age
Bovine papular stomatitis immunity lasts for how long
short term
Bovine papular stomatitis clinical symptoms
mucosal membranes, redness, papules (heals after few weeks)
no fever, no other symptoms, but can be painful => weight loss
Bovine papular stomatitis zoonotic?
yes
Bovine papular stomatitis vaccine
none
Contagious pustular dermatitis causative agent
Orf virus
Orf virus resistancy
highly resistant
(12 yrs in dried crust)
Contagious pustular dermatitis affects which animals
sheep, goat, humans
mass disease in young lambs (after lambing season)
zoonotic
Contagious pustular dermatitis pathogenesis
route of infection: mouth and foot injuries caused by rough feed
papules, serous exudates, crusts
Contagious pustular dermatitis CS
lesions lips, feet, udder, prepuce
painful: no grazing, weight loss
rarely papules in internal organs (GI, lungs & heart)
Contagious pustular dermatitis vaccine
protects for 6 months:
- Vaccine containing virulent virus: scarified into the skin in case of an outbreak
- Attenuated virus: in injectable form, can also be used in non-infected herds (no viral shedding)
